Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Nat Commun. 2020 Feb 20;11(1):987. doi: 10.1038/s41467-020-14784-1.

Abstract

Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its overexpression in wild-type increases lifespan. Jouvence is required in enterocytes. In mutant, the epithelium of the gut presents more hyperplasia, while the overexpression of jouvence prevents it. Molecularly, the mutant lack pseudouridylation on 18S and 28S-rRNA, a function rescued by targeted expression of jouvence in the gut. A transcriptomic analysis performed from the gut reveals that several genes are either up- or down-regulated, while restoring the mRNA level of two genes (ninaD or CG6296) rescue the longevity. Since snoRNAs are structurally and functionally well conserved throughout evolution, we identified putative jouvence orthologue in mammals including humans, suggesting that its function in longevity could be conserved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Conserved Sequence
  • Drosophila Proteins / genetics
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / metabolism
  • Enterocytes / metabolism
  • Evolution, Molecular
  • Female
  • Gene Deletion
  • Gene Expression Profiling
  • Genome, Insect
  • Humans
  • Intestinal Mucosa / metabolism
  • Longevity / genetics*
  • Loss of Function Mutation
  • Male
  • Mice
  • Nucleic Acid Conformation
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Small Nucleolar / chemistry
  • RNA, Small Nucleolar / genetics*
  • RNA, Small Nucleolar / metabolism
  • Receptors, Immunologic / genetics

Substances

  • Drosophila Proteins
  • NinaD protein, Drosophila
  • RNA, Messenger
  • RNA, Small Nucleolar
  • Receptors, Immunologic