Imaging of Adrenal-Related Endocrine Disorders

Radiol Clin North Am. 2020 Nov;58(6):1099-1113. doi: 10.1016/j.rcl.2020.07.010. Epub 2020 Sep 17.

Abstract

Endocrine disorders associated with adrenal pathologies can be caused by insufficient adrenal gland function or excess hormone secretion. Excess hormone secretion may result from adrenal hyperplasia or hormone-secreting (ie, functioning) adrenal masses. Based on the hormone type, functioning adrenal masses can be classified as cortisol-producing tumors, aldosterone producing tumors, and androgen-producing tumors, which originate in the adrenal cortex, as well as catecholamine-producing pheochromocytomas, which originate in the medulla. Nonfunctioning lesions can cause adrenal gland enlargement without causing hormonal imbalance. Evaluation of adrenal-related endocrine disorders requires clinical and biochemical workup associated with imaging evaluation to reach a diagnosis and guide management.

Keywords: Adrenal pathologies; Endocrine abnormality; Endocrine disorders; Excess hormone secretion; Imaging.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / pathology
  • Adrenal Gland Neoplasms / surgery
  • Adrenal Glands / diagnostic imaging
  • Adrenal Glands / metabolism
  • Adrenal Glands / pathology
  • Adrenalectomy / methods
  • Aldosterone / metabolism
  • Androgens / metabolism
  • Cushing Syndrome / diagnostic imaging*
  • Cushing Syndrome / pathology
  • Endocrine System Diseases / diagnostic imaging*
  • Endocrine System Diseases / physiopathology
  • Female
  • Humans
  • Hydrocortisone / metabolism
  • Male
  • Pheochromocytoma / diagnostic imaging*
  • Pheochromocytoma / pathology
  • Prognosis
  • Severity of Illness Index
  • Tomography, X-Ray Computed / methods*

Substances

  • Androgens
  • Aldosterone
  • Hydrocortisone