Rare primary bone sarcomas are challenging entities both radiologically and pathologically. These include the diagnoses of spindle cell sarcoma (leiomyosarcoma, fibrosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor), pleomorphic liposarcoma, and undifferentiated pleomorphic sarcoma. The radiographic and cross-sectional imaging features of each of these tumors are presented, along with current key pathological concepts. Frequently non-specific, the radiological appearances must be correlated with all clinical and pathological information available to enable an accurate diagnosis.
Keywords: Fibrosarcoma; Leiomyosarcoma; Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (UPS); Malignant peripheral nerve sheath tumor (MPNST); Pleomorphic liposarcoma; Synovial sarcoma.