Osteofibrous dysplasia and adamantinoma: A summary of diagnostic challenges and surgical techniques

Surg Oncol. 2021 Sep:38:101626. doi: 10.1016/j.suronc.2021.101626. Epub 2021 Jun 16.

Abstract

Osteofibrous dysplasia is an indolent benign fibro-osseous tumor, while adamantinoma is a locally aggressive biphasic malignancy with epithelial and fibro-osseous components. Predominantly arising in the tibial diaphysis of children and young adults, both tumors are resistant to chemotherapy and radiation. Wide surgical resection is regarded as the mainstay of therapy for adamantinoma, and limb-salvage reconstructive procedures can achieve good functional outcomes, albeit with non-negligible rates of complications. This review discusses emerging advances in the pathogenesis, histogenesis, and diagnosis of these entities and presents advantages and limitations of the most common surgical techniques used for their management.

Keywords: Adamantinoma; Limb-salvage surgery; Orthopaedic oncology; Osteofibrous dysplasia; Surgical reconstruction.

Publication types

  • Review

MeSH terms

  • Adamantinoma / diagnosis*
  • Adamantinoma / surgery
  • Bone Diseases, Developmental / diagnosis*
  • Bone Diseases, Developmental / surgery
  • Child
  • Diagnosis, Differential
  • Humans
  • Plastic Surgery Procedures / methods*

Supplementary concepts

  • Osteofibrous Dysplasia