Nutrition and bullous diseases

Victoria Stoj; Jun Lu

doi:10.1016/j.clindermatol.2021.10.009

Nutrition and bullous diseases

Clin Dermatol. 2022 Mar-Apr;40(2):156-165. doi: 10.1016/j.clindermatol.2021.10.009. Epub 2021 Nov 19.

Authors

Victoria Stoj¹, Jun Lu²

Affiliations

¹ University of Connecticut School of Medicine, Farmington, Connecticut, USA.
² Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut, USA. Electronic address: jlu@uchc.edu.

PMID: 34808244
DOI: 10.1016/j.clindermatol.2021.10.009

Abstract

Although relatively uncommon, autoimmune bullous diseases carry the risk of increased mortality and can significantly impact quality of life. This group of diseases is broad and encompasses subepidermal conditions such as bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, and linear IgA bullous dermatosis, as well as intraepidermal conditions such as pemphigus and its variants. The pathophysiology of each condition is incompletely understood but broadly involves the formation of autoantibodies targeting skin adhesion proteins, a process that relies on a complex interplay between a dysregulated immune system, genetic predisposition, and environmental factors. We review the impact of nutrition on pathogenesis, clinical course, and treatment of various autoimmune bullous diseases.

Keywords: autoimmune blistering disease; autoimmune bullous diseases; bullous diseases; bullous pemphigoid; cicatricial pemphigoid; dermatitis herpetiformis; diet; epidermolysis bullosa acquisita; food and nutrition; linear IgA bullous dermatosis; pemphigus.

Publication types

Review

MeSH terms

Autoimmune Diseases* / drug therapy
Epidermolysis Bullosa Acquisita* / drug therapy
Humans
Pemphigoid, Bullous* / drug therapy
Pemphigoid, Bullous* / etiology
Pemphigus*
Quality of Life
Skin Diseases, Vesiculobullous* / drug therapy
Skin Diseases, Vesiculobullous* / etiology