Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization

Semin Cell Dev Biol. 2023 Jan 15:133:107-122. doi: 10.1016/j.semcdb.2022.03.028. Epub 2022 Apr 5.

Abstract

During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a model system to uncover principles of how membrane and actin dynamics are co-regulated in space and time to drive morphogenesis.

Keywords: Actin; Cortical compartments; Cytokinesis; Endocytosis; Exocytosis; Membrane reservoir; Membrane trafficking; Myosin-2; Phosphoinositides.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins* / metabolism
  • Animals
  • Cell Membrane / metabolism
  • Drosophila / metabolism
  • Drosophila Proteins* / metabolism
  • Drosophila melanogaster / metabolism
  • Embryo, Nonmammalian / metabolism
  • Morphogenesis

Substances

  • Actins
  • Drosophila Proteins