Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas

S Bonvalot; C Roland; C Raut; C Le Péchoux; D Tzanis; A M Frezza; A Gronchi

doi:10.1016/j.ejso.2022.05.010

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas

Eur J Surg Oncol. 2023 Jun;49(6):1061-1067. doi: 10.1016/j.ejso.2022.05.010. Epub 2022 May 16.

Authors

S Bonvalot¹, C Roland², C Raut³, C Le Péchoux⁴, D Tzanis⁵, A M Frezza⁶, A Gronchi⁷

Affiliations

¹ Department of Surgical Oncology, Institut Curie, Paris University, Paris, France. Electronic address: Sylvie.bonvalot@curie.fr.
² Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
⁴ Department of Radiation Oncology, Gustave Roussy, Villejuif, France.
⁵ Department of Surgical Oncology, Institut Curie, Paris University, Paris, France.
⁶ Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁷ Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

PMID: 35599138
DOI: 10.1016/j.ejso.2022.05.010

Abstract

Until recently, the recommendation for primary retroperitoneal sarcomas (RPS) was to perform a complete en-bloc gross excision, (neo) adjuvant treatments being options which were not validated by randomized studies, with a large discrepancy of use between centers. The heterogeneity of RPS, with their different biological behaviour, renders a homogenous therapeutic and surgical approach probably inappropriate. Recent studies, both surgical and dedicated to adjuvant treatments, allow refining these recommendations. This review summarizes recent advances and directions.

Keywords: Chemotherapy; Diagnosis; Liposarcoma; Radiotherapy; Retroperitoneal sarcoma; Retroperitoneal tumour; Solitary fibrous Tumor; Surgery; leiomyosarcoma.

Publication types

Review

MeSH terms

Humans
Neoplasm Recurrence, Local / therapy
Retroperitoneal Neoplasms* / surgery
Retrospective Studies
Sarcoma* / surgery
Survival Rate