Pediatric Chronic Kidney Disease

Valerie Panzarino; Jake Lesser; Frank Ayestaran Cassani

doi:10.1016/j.yapd.2022.03.008

Pediatric Chronic Kidney Disease

Adv Pediatr. 2022 Aug;69(1):123-132. doi: 10.1016/j.yapd.2022.03.008.

Authors

Valerie Panzarino¹, Jake Lesser², Frank Ayestaran Cassani³

Affiliations

¹ Department of Pediatrics, Division of Pediatric Nephrology, University of South Florida Health, 2 Tampa General Circle, Fifth Floor, Tampa, FL 33606, USA. Electronic address: vpanzari@usf.edu.
² University of South Florida Health, 2 Tampa General Circle, Fifth Floor, Tampa, FL 33606, USA.
³ Department of Pediatrics, Division of Pediatric Nephrology, University of South Florida Health, 2 Tampa General Circle, Fifth Floor, Tampa, FL 33606, USA.

PMID: 35985704
DOI: 10.1016/j.yapd.2022.03.008

Abstract

Chronic kidney disease (CKD) in children has a significant impact on morbidity, mortality, and quality of life. The degree of renal dysfunction should be calculated using pediatric-specific formulas and the degree of CKD staged; this allows for appropriate dosing of medications based on renal function and monitoring for progression and comorbid conditions including metabolic acidosis, bone disease, anemia, cardiovascular complications, malnutrition and electrolyte abnormalities, growth failure, and psychosocial issues. Treatment strategies include treating the underlying disease and using general renal protective measures. Effective management of these complex issues requires a specialized multidisciplinary team approach.

Keywords: Chronic kidney disease; End-stage renal disease; Pediatrics.

Publication types

Review

MeSH terms

Acidosis* / complications
Anemia* / diagnosis
Anemia* / etiology
Anemia* / therapy
Child
Humans
Kidney
Quality of Life
Renal Insufficiency, Chronic* / complications
Renal Insufficiency, Chronic* / diagnosis
Renal Insufficiency, Chronic* / therapy