Scleredema may occur secondarily to diabetes or independently. The course of scleredema is not known in either type. Twenty-one scleredema patients were included in this study (13 females, 8 males). The patients were divided into two groups according to the presence or absence of diabetes. In the group (11 patients) of scleredema which was secondary to diabetes, lesions were partially improved in 5 patients who had controlled diabetes, although it was difficult to control diabetes with insulin or oral hypoglycemics in such patients. Scleredema appeared insidiously in nine of these eleven patients. The posterior neck was involved, but the face was not. In patients without diabetes, the scleredema lesions began acutely in eight of ten of them. The course of the disease was usually stationary rather than showing acute improvement. Facial involvement was found in half of all the patients. In conclusion, scleredema patients with diabetes may improve if their diabetes is controlled, and facial involvement may be related to scleredema without diabetes.