PXD018216

PXD018216 is an original dataset announced via ProteomeXchange.

Title	Slight deuterium enrichment in water acts as an antioxidant: is deuterium a cell growth regulator?
Description	Small admixtures in water, e.g. of metal ions, often act as cell growth regulators. Here we report that enrichment of deuterium content in water, normally found at 8 mM concentration, two-three folds increases cell proliferation and lowers the oxidative stress level as well. Acting as an anti-oxidant, deuterium-enriched water prevents the toxic effect of such oxidative agents as hydrogen peroxide and auranofin. This action is opposite to that of deuterium depletion that is known to suppress cell growth and induce oxidative stress in mitochondria. We thus hypothesize that deuterium may be a natural cell growth regulator that controls mitochondrial oxidation-reduction balance. Since growth acceleration is reduced approximately by half by addition to water a minute amount (0.15%) of 18O isotope, at least part of the deuterium effect on cell growth can be explained by the isotopic resonance phenomenon.
HostingRepository	PRIDE
AnnounceDate	2020-08-10
AnnouncementXML	Submission_2020-08-10_01:54:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuepei Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-26 04:38:44	ID requested
⏵ 1	2020-08-10 01:54:40	announced

Zhang X, Wang J, Zubarev RA, Slight Deuterium Enrichment in Water Acts as an Antioxidant: Is Deuterium a Cell Growth Regulator? Mol Cell Proteomics, 19(11):1790-1804(2020) [pubmed]

submitter keyword: deuterium-enriched water, antioxidant, oxidantion-reduction balance, cell growth regulator

Roman A Zubarev
contact affiliation	Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden SciLIfeLab, SE-17 177 Stockholm, Sweden Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, 119146, Russia
contact email	roman.zubarev@ki.se
lab head
Xuepei Zhang
contact affiliation	Karolinska Institutet
contact email	xuepei.zhang@ki.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD018216
     1. Label: PRIDE project
     2. Name: Slight deuterium enrichment in water acts as an antioxidant: is deuterium a cell growth regulator?