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CXCR4,7:CXCL12 [plasma membrane]
Stable Identifier
R-HSA-374203
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
Participants
components
CXCL12(22-93) [extracellular region]
(Homo sapiens)
CXCR4,7 [plasma membrane]
(Homo sapiens)
Participates
as an output of
Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
as a member of
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Inferred To
CXCR4,7:CXCL12 [plasma membrane]
(Bos taurus)
CXCR4,7:CXCL12 [plasma membrane]
(Danio rerio)
CXCR4,7:CXCL12 [plasma membrane]
(Gallus gallus)
CXCR4,7:CXCL12 [plasma membrane]
(Mus musculus)
CXCR4,7:CXCL12 [plasma membrane]
(Rattus norvegicus)
CXCR4,7:CXCL12 [plasma membrane]
(Sus scrofa)
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