Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Insulin [extracellular region]
Stable Identifier
R-HSA-74674
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Autophosphorylation of insulin receptor (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin binds the insulin receptor (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Binding of SHC1 to insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
IRS activation (Homo sapiens)
Binding of IRS to insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Dissociation of IRS-P from insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Phosphorylation of IRS (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Phosphorylation of SHC1 (Homo sapiens)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Signal attenuation (Homo sapiens)
Binding of Grb10 to the insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Internalisation of the insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
Participants
components
2xHC-INS(25-54) [extracellular region]
(Homo sapiens)
4xHC-INS(90-110) [extracellular region]
(Homo sapiens)
Participates
as an output of
Exocytosis of Insulin (Homo sapiens)
as an input of
Insulin binds the insulin receptor (Homo sapiens)
as a component of
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
This entity regulates
Negatively
FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter
(Homo sapiens)
FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter
(Homo sapiens)
FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter
(Homo sapiens)
Acyl Ghrelin and C-Ghrelin are secreted
(Homo sapiens)
Inferred To
Insulin [extracellular region]
(Bos taurus)
Insulin [extracellular region]
(Canis familiaris)
Insulin [extracellular region]
(Danio rerio)
Insulin [extracellular region]
(Gallus gallus)
Insulin [extracellular region]
(Mus musculus)
Insulin [extracellular region]
(Rattus norvegicus)
Insulin [extracellular region]
(Sus scrofa)
Insulin [extracellular region]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-943
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text