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About
What is Reactome ?
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GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
Stable Identifier
R-HSA-913362
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Activation of STAT5a/b by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
IL3RB is phosphorylated on Ser-585 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
JAK2 is phosphorylated, activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
The receptor is activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Tyrosine kinases phosphorylate the receptor (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from the receptor complex (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Participants
components
CSF2 [extracellular region]
(Homo sapiens)
CSF2RA [plasma membrane]
(Homo sapiens)
Participates
as a component of
GM-CSF:GM-CSF receptor alpha subunit:p(Y593)-Bc:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Homo sapiens)
as an output of
GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)
as an input of
GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)
Inferred To
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Bos taurus)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Canis familiaris)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Gallus gallus)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Mus musculus)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Rattus norvegicus)
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane]
(Sus scrofa)
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