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Budding and maturation of HIV virion
Stable Identifier
R-HSA-162588
DOI
10.3180/REACT_6359.6
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
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With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally responsible for membrane fission that creates cytoplasm filled vesicular bodies. In this case HIV (and other viruses) take advantage of the ESCRT cellular machinery to facilitate virion budding from the host.
Literature References
PubMed ID
Title
Journal
Year
22762019
HIV-1 Assembly, Budding, and Maturation
Sundquist, WI
,
Kräusslich, HG
Cold Spring Harb Perspect Med
2012
Participants
Events
Recruitment Of HIV Virion Budding Machinery
(Homo sapiens)
HIV Virion Budding
(Homo sapiens)
Maturation of HIV Virion
(Homo sapiens)
Protease binds protease inhibitors
(Homo sapiens)
Participates
as an event of
Late Phase of HIV Life Cycle (Homo sapiens)
Event Information
Go Biological Process
viral life cycle (0019058)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Gillespie, ME (2013-03-07)
Reviewed
Dube, M (2013-05-21)
Created
Joshi-Tope, G (2005-04-01)
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