Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

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R-HSA-210746
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Homo sapiens
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5/5
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Studies in mouse model systems indicate that the transcription factor neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing pancreas (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). In both mice and humans critical events in this induction process include the neurogenin 3 (NEUROG3)-dependent transcription of PAX4, NEUROD1, NKX2-2, and INSM1.
Literature References
PubMed ID Title Journal Year
15298336 Transcriptional networks controlling pancreatic development and beta cell function

Servitja, JM, Ferrer, J

Diabetologia 2004
12591178 Transcription factors direct the development and function of pancreatic beta cells

Chakrabarti, SK, Mirmira, RG

Trends Endocrinol Metab 2003
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