NFKB1:RELA translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-2730894
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Synonyms
Released NF-kB complex is transported to the nucleus
ReviewStatus
5/5
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NFKB1:RELA translocates from the cytosol to the nucleus
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The released NF-kB transcription factor (p50/p65) with unmasked nuclear localization signal (NLS) moves in to the nucleus. Once in the nucleus, NF-kB binds DNA and regulate the expression of genes encoding cytokines, cytokine receptors, and apoptotic regulators.
Literature References
PubMed ID Title Journal Year
17072321 Introduction to NF-kappaB: players, pathways, perspectives

Gilmore, TD

Oncogene 2006
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Output
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Orthologous Events
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NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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