Reactome | Role of ABL in ROBO-SLIT signaling

Role of ABL in ROBO-SLIT signaling

Stable Identifier

R-HSA-428890

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ABL (ABL1 or ABL2) plays a dual role in the ROBO pathway. As a key enzymatic component in the signaling pathway, ABL supports repellent signaling (by recruiting the necessary actin binding proteins) and also feeds back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.
ABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance.

Literature References

PubMed ID	Title	Journal	Year
15207230	Hot +TIPS: guidance cues signal directly to microtubules Kalil, K, Dent, EW	Neuron	2004
15207236	The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance Rusch, J, Engel, U, Lee, H, Sheard, K, Van Vactor, D, Scherrer, S	Neuron	2004
12441051	A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding Rusch, J, Wills, Z, Baum, B, Van Vactor, D, Bikoff, J, Perrimon, N, Emerson, M	Neuron	2002