RA biosynthesis pathway

Stable Identifier
R-HSA-5365859
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde dehydrogenase (RALDH) gene families (Das et al. 2014, Napoli 2012).
Literature References
PubMed ID Title Journal Year
21621639 Physiological insights into all-trans-retinoic acid biosynthesis

Napoli, JL

Biochim. Biophys. Acta 2012
24393720 Retinoic acid signaling pathways in development and diseases

Karki, R, Torregroza, I, Mahapatra, S, Kambhampati, S, Das, S, Evans, T, Thapa, P, Das, BC, Verma, A, Wallace, DP, Ray, SK, Van Veldhuizen, P, Liu, TC

Bioorg. Med. Chem. 2014
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