Reactome | Translation initiation complex formation

Translation initiation complex formation

Stable Identifier

R-HSA-72649

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Translation initiation complex formation

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The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.

Literature References

PubMed ID	Title	Journal	Year
6853548	New initiation factor activity required for globin mRNA translation. Tahara, SM, Morgan, MA, Grifo, JA, Merrick, WC, Shatkin, AJ	J Biol Chem	1983
592399	Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. Erni, B, Schreier, MH, Trachsel, H, Staehelin, T	J Mol Biol	1978
641056	The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. Benne, R, Hershey, JW	J Biol Chem	1978
9732867	Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Hellen, CU, Pestova, TV, Borukhov, SI	Nature	1999