Reactome | Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

Stable Identifier

R-HSA-72702

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Ribosomal scanning and start codon recognition

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The 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon of the Met-tRNAi. Proper recognition of the AUG initiation codon depends on base pairing with the anticodon of the Met-tRNAi and requires eIF1, eIF1A, eIF2 and eIF5.

Literature References

PubMed ID	Title	Journal	Year
592399	Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. Erni, B, Schreier, MH, Trachsel, H, Staehelin, T	J Mol Biol	1978
641056	The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. Benne, R, Hershey, JW	J Biol Chem	1978
	Translational Control of Gene Expression Mathews, MB, Hershey, JW, Sonenberg, N		2001
7000367	Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes. Kozak, M	Cell	1981
9732867	Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Hellen, CU, Pestova, TV, Borukhov, SI	Nature	1999