PTGIS, CYP8A1 isomerise PGH2 to PGI2

Stable Identifier
R-HSA-76496
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
Synonyms
Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2
ReviewStatus
5/5
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PTGIS, CYP8A1 isomerise PGH2 to PGI2
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Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Experiments on rats with thrombolytic models suggest endogenous MNA could be a stimulator of the COX2/PGI2 pathway and thus regulate an anti-thrombotic effect (Chlopicki et al. 2007).
Literature References
PubMed ID Title Journal Year
17641676 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway

Chlopicki, S, Lomnicka, M, Bartus, M, Swies, J, Mogielnicki, A, Gebicki, J, Buczko, W, Adamus, J

Br. J. Pharmacol. 2007
15115769 Purification and characterization of recombinant human prostacyclin synthase

Shimonishi, M, Yokoyama, C, Imai, Y, Ullrich, V, Nakamura, M, Hatae, T, Tanabe, T, Wada, M

J Biochem 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

prostaglandin-I synthase activity of PTGIS,CYP8B1 [endoplasmic reticulum membrane]

Physical Entity
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
prostaglandin-I synthase activity (GO:0008116)
Orthologous Events
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Canis familiaris)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Rattus norvegicus)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-10-01)
Reviewed
Rush, MG  (2012-11-10)
Created
Jassal, B  (2003-08-05)
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