Reactome | Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases

Stable Identifier

R-HSA-9006934

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Receptor tyrosine kinases (RTKs) are a major class of cell surface proteins involved in Signal Transduction. Human cells contain ~60 RTKs, grouped into 20 subfamilies based on their domain architecture. All RTK subfamilies are characterized by an extracellular ligand-binding domain, a single transmembrane region and an intracellular region consisting of the tyrosine kinase domain and additional regulatory and protein interaction domains. In general, RTKs associate into dimers upon ligand binding and are activated by autophosphorylation on conserved intracellular tyrosine residues. Autophosphorylation increases the catalytic efficiency of the receptor and provides binding sites for the assembly of downstream signaling complexes (reveiwed in Lemmon and Schlessinger, 2010). Common signaling pathways activated downstream of RTK activation include RAF/MAP kinase cascades (reviewed in McKay and Morrison, 2007 and Wellbrock et al 2004), AKT signaling (reviewed in Manning and Cantley, 2007) and PLC-gamma mediated signaling (reviewed in Patterson et al). Activation of these pathways ultimately results in changes in gene expression and cellular metabolism.

Literature References

PubMed ID	Title	Journal	Year
16260143	Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling Snyder, SH, Nikolaidis, N, van Rossum, DB, Gill, DL, Patterson, RL	Trends Biochem Sci	2005
15520807	The RAF proteins take centre stage Wellbrock, C, Karasarides, M, Marais, R	Nat Rev Mol Cell Biol	2004
17604717	AKT/PKB signaling: navigating downstream Manning, BD, Cantley, LC	Cell	2007
17496910	Integrating signals from RTKs to ERK/MAPK McKay, MM, Morrison, DK	Oncogene	2007
20602996	Cell signaling by receptor tyrosine kinases Schlessinger, J, Lemmon, MA	Cell	2010