Reactome | STEAP3,STEAP4 reduce Fe3+ to Fe2+

STEAP3,STEAP4 reduce Fe3+ to Fe2+

Stable Identifier

R-HSA-917811

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome lumen, endosome membrane

Synonyms

2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+), Reduction of Fe3+ in the endosome

ReviewStatus

4/5

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The iron ions that are no longer bound to transferrin are reduced by the metalloreductases STEAP3 and STEAP4, two endosomal membrane proteins, while they are transported through the membrane. The electron donor partner of the enzyme is NADPH (Ohgami et al., 2005; Ohgami et al., 2006; Kleven et al., 2015; Oosterheert et al., 2018).

Literature References

PubMed ID	Title	Journal	Year
16227996	Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells Fleming, MD, Ohgami, RS, Fujiwara, Y, Chen, J, Antiochos, B, Greer, EL, Campagna, DR, Barker, JE, McDonald, A, Sharp, JJ	Nat Genet	2005
30337524	Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction Oosterheert, W, Granneman, J, Mattevi, A, van Bezouwen, LS, Gros, P, Förster, F, Rodenburg, RNP	Nat Commun	2018
26205815	Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins Dlakić, M, Lawrence, CM, Kleven, MD	J Biol Chem	2015
16609065	The Steap proteins are metalloreductases Fleming, MD, Ohgami, RS, Campagna, DR, McDonald, A	Blood	2006