SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+

Stable Identifier
R-HSA-917933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Oxidation of Fe2+ by hephaestin
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Hephaestin oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+) after export from duodenal cells to enable its transport via transferrin (Griffiths et al, 2005).
Literature References
PubMed ID Title Journal Year
16274220 Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity

Mauk, AG, MacGillivray, RT, Griffiths, TA

Biochemistry 2005
Participants
Participates
Catalyst Activity

ferroxidase activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!