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FLT3 Signaling
Stable Identifier
R-HSA-9607240
DOI
10.3180/R-HSA-9607240.5
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
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|
PNG
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PPTX
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SBGN
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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) (also known as FLK2 (fetal liver tyrosine kinase 2), STK-1 (stem cell tyrosine kinase 1) or CD135) is a member of the class III receptor tyrosine kinase family involved in the differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Upon FLT3 ligand (FL) binding, the receptor forms dimers and is phosphorylated. Consequently, adapter and signaling molecules bind with the active receptor and trigger the activation of various pathways downstream including PI3K/Akt and MAPK cascades (Grafone T et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
25992210
An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment
Storti, S
,
Nicci, C
,
Grafone, T
,
Palmisano, M
Oncol Rev
2012
Participants
Events
FLT3LG dimer binds FLT3
(Homo sapiens)
FLT3LG dimer:FLT3 binds FLT3
(Homo sapiens)
FLT3LG dimer:FLT3 dimer autophosphorylates
(Homo sapiens)
FLT3 signaling through SRC family kinases
(Homo sapiens)
Active FLT3 binds to GRAP2
(Homo sapiens)
Active FLT3 binds to GRB10
(Homo sapiens)
FLT3 phosphorylates GRB10
(Homo sapiens)
Active FLT3:p-Y-GRB10 binds PIK3R1
(Homo sapiens)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
(Homo sapiens)
Active FLT3 dimer binds GRB2
(Homo sapiens)
Active FLT3:GRB2 binds SOS1
(Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3
(Homo sapiens)
Active FLT3:GRB2 binds GAB2
(Homo sapiens)
GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
(Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
(Homo sapiens)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
(Homo sapiens)
AKT phosphorylates FOXO3 downstream of FLT3
(Homo sapiens)
AKT-phosphorylated FOXO3 translocates to cytosol
(Homo sapiens)
FOXO3-dependent BCL2L11 gene expression
(Homo sapiens)
FOXO3-dependent CDKN1B gene expression
(Homo sapiens)
Active FLT3 phosphorylates CDKN1B
(Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
(Homo sapiens)
Active FLT3 binds PTPN11
(Homo sapiens)
STAT5 Activation
(Homo sapiens)
FLT3 binds type I TKI
(Homo sapiens)
FLT3 binds type II TKI
(Homo sapiens)
Negative regulation of FLT3
(Homo sapiens)
Participates
as an event of
Cytokine Signaling in Immune system (Homo sapiens)
Event Information
Go Biological Process
cytokine-mediated signaling pathway (0019221)
Orthologous Events
FLT3 Signaling (Bos taurus)
FLT3 Signaling (Caenorhabditis elegans)
FLT3 Signaling (Canis familiaris)
FLT3 Signaling (Danio rerio)
FLT3 Signaling (Drosophila melanogaster)
FLT3 Signaling (Gallus gallus)
FLT3 Signaling (Mus musculus)
FLT3 Signaling (Rattus norvegicus)
FLT3 Signaling (Sus scrofa)
FLT3 Signaling (Xenopus tropicalis)
Reviewed
Joshi, S (2019-08-16)
Traer, E (2019-05-03)
Kazi, JU (2020-11-06)
Created
Varusai, TM (2018-05-01)
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