Ltc4s (leukotriene C4 synthase) - Rat Genome Database

Name: Ltc4s
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ltc4s (leukotriene C4 synthase) Rattus norvegicus

Analyze

Symbol:

Ltc4s

Name:

leukotriene C4 synthase

RGD ID:

620677

Description:

Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipid; leukotriene biosynthetic process; and response to axon injury. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Biomarker of glomerulonephritis and peripheral nervous system disease. Orthologous to human LTC4S (leukotriene C4 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glutathione S-transferase LTC4; leukotriene-C(4) synthase; LTC4 synthase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LTC4S (leukotriene C4 synthase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BMERB1 (bMERB domain containing 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LTC4S (leukotriene C4 synthase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ltc4s (leukotriene C4 synthase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ltc4s (leukotriene C4 synthase)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ltc4s.2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Candidate Gene For:

Bmd4

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,060,002 - 35,066,466 (-)	NCBI		GRCr8
mRatBN7.2	10	34,560,476 - 34,562,790 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	34,560,360 - 34,562,651 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,235,902 - 39,237,857 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	7,775,154 - 7,777,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,229,574 - 34,231,529 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	35,736,486 - 35,743,088 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	35,737,664 - 35,739,625 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	35,498,195 - 35,506,088 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	35,786,877 - 35,788,838 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	35,787,925 - 35,789,881 (-)	NCBI
Celera	10	33,909,805 - 33,911,766 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (IEP)

acute promyelocytic leukemia (ISO)

aspirin-induced respiratory disease (ISO)

asthma, nasal polyps, and aspirin intolerance (ISO)

drug allergy (ISO)

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (ISO)

glomerulonephritis (IEP)

Leukotriene C4 Synthase Deficiency (ISO)

otitis media (ISO)

peripheral nervous system disease (IEP)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

7,12-dimethyltetraphene (EXP)

acetamide (EXP)

acetohydrazide (ISO)

acetylsalicylic acid (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP)

bucladesine (ISO)

carbon nanotube (ISO)

chlorohydrocarbon (EXP)

chromium(6+) (ISO)

chrysene (ISO)

clofibric acid (EXP)

colforsin daropate hydrochloride (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

diclofenac (EXP)

diethyl maleate (EXP)

etazolate (ISO)

flavonoids (EXP)

fucoxanthin (ISO)

furan (EXP)

glucose (ISO)

histamine (ISO)

leukotriene C4 (ISO)

lipopolysaccharide (ISO)

methamphetamine (EXP)

methylmercury chloride (EXP)

montelukast (ISO)

N-nitrosodiethylamine (EXP)

orphenadrine (EXP)

parthenolide (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

rolipram (ISO)

SB 203580 (ISO)

SCH 23390 (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

tetrachloromethane (ISO)

tetraphene (ISO)

theophylline (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

troglitazone (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (IEA)

cellular response to lipopolysaccharide (IEP)

cellular response to vitamin A (IEP)

leukotriene biosynthetic process (IBA,IDA,IEA,TAS)

leukotriene metabolic process (ISO)

long-chain fatty acid biosynthetic process (IEA,ISO,ISS)

response to axon injury (IEP)

response to inorganic substance (IEP)

response to lipopolysaccharide (IEP)

response to xenobiotic stimulus (IEP)

Cellular Component

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum membrane (IEA,ISO,ISS)

nuclear envelope (IBA,ISO)

nuclear membrane (ISO,ISS)

nuclear outer membrane (IEA,ISO,ISS)

Molecular Function

enzyme activator activity (IEA)

glutathione binding (IDA)

glutathione peroxidase activity (IBA)

glutathione transferase activity (IBA)

identical protein binding (ISO)

leukotriene-C4 synthase activity (IBA,IDA,IEA,ISO)

lipid binding (ISO)

protein binding (ISO)

protein-containing complex binding (IPI)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (IEA,ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

leukotriene metabolic pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone.	Abe M, etal., J Cell Physiol 2003 Jul;196(1):154-64.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4.	Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.	Ma KF, etal., World J Gastroenterol. 2008 May 7;14(17):2748-56.
6.	The membrane organization of leukotriene synthesis.	Mandal AK, etal., Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. Epub 2004 Apr 14.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.	Okubo M, etal., Glia. 2010 Apr;58(5):599-610.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.	Petric R, etal., Biochim Biophys Acta. 1995 Jan 20;1254(2):207-15.
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs.	Schroder O, etal., Biochem Biophys Res Commun. 2003 Dec 12;312(2):271-6.
17.	Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.	Schroder O, etal., Cell Mol Life Sci. 2005 Jan;62(1):87-94.
18.	Expression and regulation of leukotriene-synthesis enzymes in rat liver cells.	Shimada K, etal., Hepatology. 1998 Nov;28(5):1275-81.
19.	High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.	Wetterholm A, etal., Protein Expr Purif. 2008 Jul;60(1):1-6. Epub 2008 Mar 23.
20.	Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats.	Yang SL and Lou YJ, Biochem Pharmacol. 2007 Mar 1;73(5):724-35. Epub 2006 Nov 18.
21.	Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway.	Yang SL, etal., Pharmacology. 2007;80(1):11-20. Epub 2007 May 10.

Additional References at PubMed

PMID:7599836	PMID:8706658	PMID:9153254	PMID:11319240	PMID:12023288	PMID:12445492	PMID:15530365	PMID:16552728	PMID:17397868	PMID:17632546	PMID:17632548	PMID:18053799
PMID:19233132	PMID:23505109	PMID:25540197	PMID:27791009

Genomics

Comparative Map Data

Ltc4s
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,060,002 - 35,066,466 (-)	NCBI		GRCr8
mRatBN7.2	10	34,560,476 - 34,562,790 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	34,560,360 - 34,562,651 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,235,902 - 39,237,857 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	7,775,154 - 7,777,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,229,574 - 34,231,529 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	35,736,486 - 35,743,088 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	35,737,664 - 35,739,625 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	35,498,195 - 35,506,088 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	35,786,877 - 35,788,838 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	35,787,925 - 35,789,881 (-)	NCBI
Celera	10	33,909,805 - 33,911,766 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

LTC4S
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	179,793,986 - 179,796,647 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	179,793,980 - 179,796,647 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	179,220,987 - 179,223,648 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	179,153,592 - 179,156,119 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	179,153,591 - 179,156,119	NCBI
Celera	5	174,846,142 - 174,848,669 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	173,947,161 - 173,949,688 (+)	NCBI		HuRef
CHM1_1	5	178,653,394 - 178,655,921 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	180,349,182 - 180,351,843 (+)	NCBI		T2T-CHM13v2.0

Ltc4s
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,127,288 - 50,129,378 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,127,288 - 50,129,443 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	50,236,461 - 50,238,532 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	50,236,461 - 50,238,616 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,049,974 - 50,051,973 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,079,895 - 50,081,894 (-)	NCBI		MGSCv36	mm8
Celera	11	54,797,050 - 54,799,049 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.4	NCBI

Ltc4s
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	788,856 - 791,505 (-)	NCBI	ChiLan1.0	ChiLan1.0

LTC4S
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	174,735,060 - 174,739,519 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	172,874,599 - 172,879,058 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	174,946,346 - 174,950,805 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	182,256,113 - 182,261,003 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

LTC4S
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	1,893,927 - 1,897,028 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	1,894,380 - 1,897,752 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	2,012,534 - 2,020,224 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	1,863,608 - 1,871,298 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	1,867,307 - 1,871,411 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	1,835,205 - 1,842,895 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	1,914,372 - 1,922,062 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	2,154,596 - 2,162,286 (-)	NCBI		UU_Cfam_GSD_1.0

Ltc4s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	119,765,712 - 119,768,688 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936739	975,493 - 978,482 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936739	975,494 - 978,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LTC4S
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	78,799,449 - 78,802,285 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	78,799,446 - 78,802,281 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	80,365,497 - 80,368,339 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LTC4S
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	81,523,784 - 81,526,297 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	81,523,775 - 81,526,179 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	12,900,551 - 12,903,368 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ltc4s
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	42,670,632 - 42,672,846 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	42,668,963 - 42,673,385 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ltc4s
8 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	73
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000004359
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			15	15		15			2		1	1
Low	3	39	37	21	19	21	8	11	62	21	35	10	8
Below cutoff		4	5	5		5			10	14	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB048790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000004359 ⟹ ENSRNOP00000004359

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	34,560,555 - 34,561,801 (-)	Ensembl
Rnor_6.0 Ensembl	10	35,737,664 - 35,739,625 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110795 ⟹ ENSRNOP00000087343

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	34,560,360 - 34,562,651 (-)	Ensembl

RefSeq Acc Id:

NM_053639 ⟹ NP_446091

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,061,633 - 35,063,594 (-)	NCBI
mRatBN7.2	10	34,560,555 - 34,562,516 (-)	NCBI
Rnor_6.0	10	35,737,664 - 35,739,625 (-)	NCBI
Rnor_5.0	10	35,498,195 - 35,506,088 (-)	NCBI
RGSC_v3.4	10	35,786,877 - 35,788,838 (-)	RGD
Celera	10	33,909,805 - 33,911,766 (-)	RGD

Sequence:

show sequence

GCTAATTCTGCCTGTGGCTGGCAACATGAAGGAAGAAACAGCTCTTCTGGCTACCGTCACCCTC
GTGGGAGTTCTGCTGCAAGCCTACTTCTCCCTACAGGTGATCTCTGCGCGAAGAACTTTCCACG
TGTCGCCGCCGCTCACCTCTGGCCCTCCCGAGTTCGAGCGCGTCTTCCGAGCCCAGGTAAATTG
CAGCGAGTACTTTCCGCTGTTCCTCGCCACGCTCTGGGTCGCCGGCATCTTCTTCCACGAAGGC
GCCGCAGCCCTGTGCGGGCTGTTCTACCTGTTCGCGCGGCTCCGCTACTTCCAGGGATACGCGC
GCTCCGCACAGCACAGGCTGGATCCCCTGTACGCGAGCGCGCGCGCGCTCTGGCTGCTAGTGGC
AATGGCTGCACTGGGCTTGCTAGTCCACTTCCTCCCTGGCACACTACGGGCTGCGCTCTTCAGA
TGGCTCCAGGTGCTCCTGCCGATGGCCTGAGGCGAAGGCCCTCCGAATCAGCAGAACT

hide sequence

RefSeq Acc Id:

XM_006246219 ⟹ XP_006246281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,061,562 - 35,063,505 (-)	NCBI
mRatBN7.2	10	34,560,484 - 34,562,427 (-)	NCBI
Rnor_6.0	10	35,736,486 - 35,739,535 (-)	NCBI
Rnor_5.0	10	35,498,195 - 35,506,088 (-)	NCBI

Sequence:

show sequence

GGCTCCTGTCTGGGGGATGGGTGGATCTTAGACCTACGCAGCCTGCTCTCCGTCCTTCAGCCCC
TTGGGGTAGGGAATTGGGGTGCTGGCAGGCCTAGGCTCAGGTGAAGGACAGGAGCTTCTAGCCT
AGGCTCCTGGTACCAAGCTCTTCAAGAACTACTGGAGTCTTGGGTGCTGGAGTCCCTAAGCCCC
ATCCAAGGAGCCCATACTTCCCTAGAGTGAGGATGAAGCCCCCAAGGAGTGTGTACAGGGGAGC
AGAGGAAACTGTGCATGGGTCAACCGAGGAGGACCAGGTGATCTCTGCGCGAAGAACTTTCCAC
GTGTCGCCGCCGCTCACCTCTGGCCCTCCCGAGTTCGAGCGCGTCTTCCGAGCCCAGGTAAATT
GCAGCGAGTACTTTCCGCTGTTCCTCGCCACGCTCTGGGTCGCCGGCATCTTCTTCCACGAAGG
CGCCGCAGCCCTGTGCGGACTGTTCTACCTGTTCGCGCGGCTCCGCTACTTCCAGGGATACGCG
CGCTCCGCACAGCACAGGCTGGATCCCCTGTACGCGAGCGCGCGCGCGCTCTGGCTGCTAGTGG
CAATGGCTGCACTGGGCTTGCTAGTCCACTTCCTCCCTGGCACACTACGGGCTGCGCTCTTCAG
ATGGCTCCAGGTGCTCCTGCCGATGGCCTGAGGCGAAGGACCTCCAAGTCAGCAGAACTGGAGA
TCTTCGAACTAAACGCTGGGGCGCCCACCTCCGAATCCCAATTTCTAATTAAAGTTTCCACGAA
GATCCCGTCTGCATTTTCTTGGTCTGAGGAGGGTCGCATACCGCAGGCTGCGAAGCCTGGAGGG
CCCCAACCCGGGACAGATGCAGCCGGGCTTTGGGAGGTAGCATAGGCAAGCTTGGTTTCATCCT
TCTCATAGTACTGTCTTCTAGACAACATCTTGCCTGAGCAGCTACTTCTGCCTTGACATTTATT
TCCAGAGATAGCCTCCCTTCACCCACCTTTCTGTACTTGGGGTTCATCTTCCTCTCAGGCTGAG
CCTCAGTCATTGGATTCTTCCTTGTATGCCTTCTTGTCCCCTACACCCACCCGACGTCACAACT
AGAACCAGTCTTTCCCCGAGTGAGATCTGGGTCCCTGTTTTGGATCAGCGCTAGATCTCCAAAT
AGAGATTAGTGTAGGTGTTCAGGACACCCCTACAAAGGCCCACACAGCAGTGAGCATGACCAAA
AATGTAGTCAGTGATAGGTTCTCAAGTGGACCTCAGGATGCTTGAAAAGACTTGGGTATGCCTA
CTGACAATACACCTCTAAATGACTTTTAACCTACCTGGCCAGCAAAAATGCTTCTCAAACAGGC
CTAACAATGTGTGGGTGGAGATGGGCCGTTTATTTTAGAAATGACCACAGTATAAGCTAGGAGT
TGTGGTATAGTTGTAATCTTAGTACTTAGGAAGTGGAGGCATAAATTCATGGCCAGCTTGGGTT
ACAGTGAGTTCCAGCACTCCCTGACTGTCTCAATCCCCTGTCCACACCAAGATCCTATTATATG
AGACAAGGAGAGAAGCAGGGAGCACGAGACTAAGGACTAAGTGTGTGTGTGGGGGGAGGGGATT
GGCAAACACTCCCCATCCCGAGGCGCTCAGGTCTGTGCAGTAGTTGGGCTGGGTAATGTTGCCA
GACCAGGATGCTCTGAGAACACATTGGACAGGGATTCCTACAGGATAGGTGCATGAAACCCCCA
GTTACTGACTCAGTGGTCACGACTTTCCTGCTAAGTAAAGATGAGGTTACCGCTGAGGTATGCC
AACAGAAATTTGACATGGTAAAGGAGGGTCTGGGACTTAGTCCTTGGTATGACAGAGATCAAAG
TCACCTTTGATCAAGTAACCA

hide sequence

RefSeq Acc Id:

XM_039085020 ⟹ XP_038940948

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,061,562 - 35,063,684 (-)	NCBI
mRatBN7.2	10	34,560,484 - 34,562,624 (-)	NCBI

RefSeq Acc Id:

XM_063268266 ⟹ XP_063124336

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,060,002 - 35,066,466 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446091	(Get FASTA)	NCBI Sequence Viewer
	XP_006246281	(Get FASTA)	NCBI Sequence Viewer
	XP_038940948	(Get FASTA)	NCBI Sequence Viewer
	XP_063124336	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB58882	(Get FASTA)	NCBI Sequence Viewer
	EDM04261	(Get FASTA)	NCBI Sequence Viewer
	EDM04262	(Get FASTA)	NCBI Sequence Viewer
	EDM04263	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004359
	ENSRNOP00000004359.2
	ENSRNOP00000087343.1
GenBank Protein	Q925U2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446091 ⟸ NM_053639
- UniProtKB:	Q925U2 (UniProtKB/Swiss-Prot), G3V6E6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKEETALLATVTLVGVLLQAYFSLQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYFPLFL ATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVAMAALGLLV HFLPGTLRAALFRWLQVLLPMA hide sequence

RefSeq Acc Id:	XP_006246281 ⟸ XM_006246219
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2Q1E0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPPRSVYRGAEETVHGSTEEDQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYFPLFLAT LWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVAMAALGLLVHF LPGTLRAALFRWLQVLLPMA hide sequence

RefSeq Acc Id:

ENSRNOP00000004359 ⟸ ENSRNOT00000004359

RefSeq Acc Id:	XP_038940948 ⟸ XM_039085020
- Peptide Label:	isoform X3
- UniProtKB:	A6HE07 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000087343 ⟸ ENSRNOT00000110795

RefSeq Acc Id:	XP_063124336 ⟸ XM_063268266
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q925U2-F1-model_v2	AlphaFold	Q925U2	1-150	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697151

Promoter ID:

EPDNEW_R7676

Type:

single initiation site

Name:

Ltc4s_1

Description:

leukotriene C4 synthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	35,739,627 - 35,739,687	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620677	AgrOrtholog
BioCyc Gene	G2FUF-25248	BioCyc
BioCyc Pathway	PWY66-375 [leukotriene biosynthesis]	BioCyc
BioCyc Pathway Image	PWY66-375	BioCyc
Ensembl Genes	ENSRNOG00000003244	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004359	ENTREZGENE
	ENSRNOT00000004359.3	UniProtKB/TrEMBL
	ENSRNOT00000110795.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	5_LipOase_AP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FLAP/GST2/LTC4S_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAPEG-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Membr-assoc_MAPEG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:114097	UniProtKB/Swiss-Prot
NCBI Gene	114097	ENTREZGENE
PANTHER	LEUKOTRIENE C4 SYNTHASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MICROSOMAL GLUTATHIONE S-TRANSFERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MAPEG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	LTC4S	RGD
PhenoGen	Ltc4s	PhenoGen
PRINTS	5LPOXGNASEAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	FLAP_GST2_LTC4S	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003244	RatGTEx
Superfamily-SCOP	SSF161084	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A7K1_RAT	UniProtKB/TrEMBL
	A0A8L2Q1E0	ENTREZGENE, UniProtKB/TrEMBL
	A6HE06_RAT	UniProtKB/TrEMBL
	A6HE07	ENTREZGENE, UniProtKB/TrEMBL
	G3V6E6	ENTREZGENE
	LTC4S_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	G3V6E6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Ltc4s	leukotriene C4 synthase			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Ltc4s	leukotriene C4 synthase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	inhibited by steroids at the transcriptional level	724432

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways