Novak1997 - Cell Cycle

Model Identifier
BIOMD0000000007
Short description
Novak1997 - Cell Cycle

Modeling the control of DNA replication in fission yeast.

This model is described in the article:

Modeling the control of DNA replication in fission yeast.
Novak B., Tyson JJ.
Proc. Natl. Acad. Sci. U.S.A. 1997:94(17):9147-52

Abstract:

A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S phase). Strict controls normally operate to prevent repeated rounds of DNA replication without intervening mitoses ("endoreplication") or initiation of mitosis before DNA is fully replicated ("mitotic catastrophe"). Some of the genetic interactions involved in these controls have recently been identified in yeast. From this evidence we propose a molecular mechanism of "Start" control in Schizosaccharomyces pombe. Using established principles of biochemical kinetics, we compare the properties of this model in detail with the observed behavior of various mutant strains of fission yeast: wee1(-) (size control at Start), cdc13Delta and rum1(OP) (endoreplication), and wee1(-) rum1Delta (rapid division cycles of diminishing cell size). We discuss essential features of the mechanism that are responsible for characteristic properties of Start control in fission yeast, to expose our proposal to crucial experimental tests.

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Format
SBML (L2V3)
Related Publication
  • Modeling the control of DNA replication in fission yeast.
  • Novak B, Tyson JJ
  • Proceedings of the National Academy of Sciences of the United States of America , 8/ 1997 , Volume 94 , pages: 9147-9152 , PubMed ID: 9256450
Contributors
Submitter of the first revision: Nicolas Le Novère
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Nicolas Le Novère

Metadata information

is (2 statements)
BioModels Database BIOMD0000000007
BioModels Database MODEL6614787694

isDescribedBy (1 statement)
PubMed 9256450

isDerivedFrom (1 statement)
PubMed 10395816

hasTaxon (1 statement)
isVersionOf (2 statements)
Gene Ontology mitotic cell cycle
KEGG Pathway Cell cycle

isHomologTo (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources