This model is according to the paper Cellular consequences of HEGR mutations in the long QT syndrome: precursors to sudden cardiac death. The author used Markovian model of cardiac Ikr in the paper. Figure4B in the paper has been reproduced using CellDesigner3.5.1. The cell is depolarized to the indicated test potential for 250ms (from 50ms to 300ms) from a holding potential of -40mV and then repolarized to -40mV. Change the value for vtest from -30,-20,-10,0,10,20,30,40 for each simulation in order to produce the different cureve in the paper.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.
- C E Clancy, Y Rudy
- Cardiovascular research , 5/ 2001 , Volume 50 , Issue 2 , pages: 301-313 , PubMed ID: 11334834
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Enuo He
Metadata information
isDescribedBy (1 statement)
isDerivedFrom (4 statements)
hasTaxon (1 statement)
isVersionOf (3 statements)
Gene Ontology delayed rectifier potassium channel activity
Gene Ontology regulation of potassium ion transport
isHomologTo (1 statement)
hasVersion (1 statement)
hasProperty (1 statement)
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