Clancy2001_Kchannel

Model Identifier
BIOMD0000000121
Short description

This model is according to the paper Cellular consequences of HEGR mutations in the long QT syndrome: precursors to sudden cardiac death. The author used Markovian model of cardiac Ikr in the paper. Figure4B in the paper has been reproduced using CellDesigner3.5.1. The cell is depolarized to the indicated test potential for 250ms (from 50ms to 300ms) from a holding potential of -40mV and then repolarized to -40mV. Change the value for vtest from -30,-20,-10,0,10,20,30,40 for each simulation in order to produce the different cureve in the paper.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V1)
Related Publication
  • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.
  • C E Clancy, Y Rudy
  • Cardiovascular research , 5/ 2001 , Volume 50 , Issue 2 , pages: 301-313 , PubMed ID: 11334834
Contributors
Submitter of the first revision: Enuo He
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Enuo He

Metadata information

is (2 statements)
BioModels Database BIOMD0000000121
BioModels Database MODEL2898180293

isDescribedBy (1 statement)
PubMed 11334834

isDerivedFrom (4 statements)
PubMed 10318671
PubMed 10448858
PubMed 7514509
PubMed 7788872

hasTaxon (1 statement)
Taxonomy Cavia porcellus

isVersionOf (3 statements)
isHomologTo (1 statement)
OMIM 152427

hasVersion (1 statement)
Human Disease Ontology Andersen-Tawil syndrome

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources