Morris2002_CellCycle_CDK2Cyclin

Model Identifier
BIOMD0000000150
Short description

Notes from the original DOCQS curator:
In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. 277(26):23847-53 .

Notes from BioModels DB curator:
Although the parameters are those reported in the table I for CDK2/Cyclin A, the total fluorescence follows exactly the curve reported in the paper for CDK2/Cyclin H in figure 1B. Either the plot legend or the table is wrong.

Format
SBML (L2V1)
Related Publication
  • Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.
  • May C Morris, Claire Gondeau, John A Tainer, Gilles Divita
  • The Journal of biological chemistry , 6/ 2002 , Volume 277 , Issue 26 , pages: 23847-23853 , PubMed ID: 11959850
Contributors
Submitter of the first revision: Sharat Vayttaden
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Sharat Vayttaden

Metadata information

is (2 statements)
BioModels Database BIOMD0000000150
BioModels Database MODEL4821491663

isDescribedBy (1 statement)
PubMed 11959850

hasTaxon (1 statement)
isVersionOf (2 statements)
Gene Ontology mitotic cell cycle
KEGG Pathway Cell cycle

isHomologTo (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources