The model reproduces the oscillations for mRNA and protein species as depicted in Fig 3 of the plot. The model differs slightly from that given in the paper and this was made after a communication from the authors. The values of parameters tcvriclkp, tcdvpmt and dccpt are slightly different. Also, although it is not given in the paper, rate laws for reactions re20, re28, re35, re42, re43 and re45 are multiplied by a specie. Model was successfully tested on MathSBML
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Modelling of circadian rhythms in Drosophila incorporating the interlocked PER/TIM and VRI/PDP1 feedback loops.
- Z Xie, Kulasiri D
- Journal of theoretical biology , 3/ 2007 , Volume 245 , Issue 2 , pages: 290-304 , PubMed ID: 17157878
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Harish Dharuri
Metadata information
Gene Ontology circadian rhythm
Gene Ontology regulation of circadian sleep/wake cycle, sleep
BioModels Database MODEL1029395046
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