Model Identifier
BIOMD0000000180
Short description

This model is from the article:
Interlinked mutual inhibitory positive feedbacks induce robust cellular memory effects.
Kim TH, Jung SH, Cho KH FEBS Lett.2007 Oct; 581(25) 17892872,
Abstract:
Mutual inhibitory positive feedback (MIPF), or double-negative feedback, is a key regulatory motif of cellular memory with the capability of maintaining switched states for transient stimuli. Such MIPFs are found in various biological systems where they are interlinked in many cases despite a single MIPF can still realize such a memory effect. An intriguing question then arises about the advantage of interlinking MIPFs instead of exploiting an isolated single MIPF to realize the memory effect. We have investigated the advantages of interlinked MIPF systems through mathematical modeling and computer simulations. Our results revealed that interlinking MIPFs expands the parameter range of achieving the memory effect, or the memory region, thereby making the system more robust to parameter perturbations. Moreover, the minimal duration and amplitude of an external stimulus required for off-to-on state transition are increased and, as a result, external noises can more effectively be filtered out. Hence, interlinked MIPF systems can realize more robust cellular memories with respect to both parameter perturbations and external noises. Our study suggests that interlinked MIPF systems might be an evolutionary consequence acquired for a more reliable memory effect by enhancing robustness against noisy cellular environments.

Note: The model reproduces the simulation result for the symmetric model as depicted in Fig 3H of the paper. Model successfully tested on MathSBML

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2012 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • Interlinked mutual inhibitory positive feedbacks induce robust cellular memory effects.
  • Tae-Hwan Kim, Sung Hoon Jung, Kwang-Hyun Cho
  • FEBS letters , 10/ 2007 , Volume 581 , Issue 25 , pages: 4899-4904 , PubMed ID: 17892872
Contributors
Submitter of the first revision: Harish Dharuri
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Harish Dharuri

Metadata information

is (2 statements)
BioModels Database BIOMD0000000180
BioModels Database MODEL8716097586

isDescribedBy (1 statement)
PubMed 17892872

hasTaxon (1 statement)
isVersionOf (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


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