Model Identifier
BIOMD0000000183
Short description
Stefan2008 - calmodulin allostery

An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed (R)] state.

This model is described in the article:

Stefan MI, Edelstein SJ, Le Novère N
Proc. Natl. Acad. Sci. U.S.A. 2008 Aug; 105(31): 10768-10773

Abstract:

Calmodulin plays a vital role in mediating bidirectional synaptic plasticity by activating either calcium/calmodulin-dependent protein kinase II (CaMKII) or protein phosphatase 2B (PP2B) at different calcium concentrations. We propose an allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed (R)] state. The four calcium-binding sites are assumed to be nonidentical. The model is consistent with previously reported experimental data for calcium binding to calmodulin. It also accounts for known properties of calmodulin that have been difficult to model so far, including the activity of nonsaturated forms of calmodulin (we predict the existence of open conformations in the absence of calcium), an increase in calcium affinity once calmodulin is bound to a target, and the differential activation of CaMKII and PP2B depending on calcium concentration.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • An allosteric model of calmodulin explains differential activation of PP2B and CaMKII.
  • Melanie I Stefan, Stuart J Edelstein, Nicolas Le Novère
  • Proceedings of the National Academy of Sciences of the United States of America , 8/ 2008 , Volume 105 , Issue 31 , pages: 10768-10773 , PubMed ID: 18669651
Contributors
Submitter of the first revision: Melanie Stefan
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Melanie Stefan

Metadata information

is (2 statements)
BioModels Database BIOMD0000000183
BioModels Database MODEL9885984404

isDescribedBy (1 statement)
PubMed 18669651

hasTaxon (1 statement)
Taxonomy Mammalia

isVersionOf (5 statements)
isPartOf (2 statements)
Reactome CaM pathway
KEGG Pathway Long-term potentiation


Curation status
Curated


Connected external resources