Santolini2001_nNOS_Mechanism_Regulation

Model Identifier
BIOMD0000000199
Short description
This is a model of neuronal Nitric Oxide Synthase expressed in Escherichia coli based on Santolini J. et al. J Biol Chem. (2001) 276(2):1233-43.
Differing from the article, oxygen explicitly included in the reaction 2, 5 and 10 (numbers as in scheme 1 in the article). In the article the assumed oxygen concentration of 140 uM was included in the pseudo first order rate constant.
Fig 2E in the article shows different time courses for citrulline and NO than the ones produced by this model. Dr. Santolini, one of the authors of the article, wrote that the legends in fig. 2E might be mixed up and should rather denote NO and NO3 instead of citrulline and NO.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
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To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Format
SBML (L2V3)
Related Publication
  • A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.
  • J Santolini, S Adak, C M Curran, D J Stuehr
  • The Journal of biological chemistry , 1/ 2001 , Volume 276 , Issue 2 , pages: 1233-1243 , PubMed ID: 11038356
Contributors
Submitter of the first revision: Sharat Vayttaden
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Sharat Vayttaden

Metadata information

is (2 statements)
BioModels Database BIOMD0000000199
BioModels Database MODEL4734733125

isDescribedBy (1 statement)
PubMed 11038356

hasTaxon (1 statement)
isVersionOf (1 statement)
hasVersion (1 statement)
OMIM 163731

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources