Hofmeyer1986_SeqFb_Proc_AA_Synthesis

Model Identifier
BIOMD0000000284
Short description

This model is the reaction sequence SEQFB, a model pathway of a branched system with sequential feedback interactions found in bacterial amino acid synthesis. Its steady state is presented in Fig 4.

The model is described in:
METAMOD: software for steady-state modelling and control analysis of metabolic pathways on the BBC microcomputer.
JHS Hofmeyr and KJ van der Merwe, Comput Appl Biosci 1986 2:243-9; PubmedID: 3450367
Abstract:
METAMOD, a BBC microcomputer-based software package for steady-state modelling and control analysis of model metabolic pathways, is described, The package consists of two programs. METADEF allows the user to define the pathway in terms of reactions, rate equations and initial concentrations of metabolites. METACAL uses one of two algorithms to calculate the steady-state concentrations and fluxes. One algorithm uses the current ratio of production and consumption rates of variable metabolites to adjust iteratively their concentrations in such a way that they converge towards the steady state. The other algorithm solves the roots of the system equations by means of a quasi-Newtonian procedure. Control analysis allows the calculation of elasticity, control and response coefficients, by means of finite difference approximation. METAMOD is interactive and easy to use, and suitable for teaching and research purposes.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novere N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • METAMOD: software for steady-state modelling and control analysis of metabolic pathways on the BBC microcomputer.
  • J H Hofmeyr, K J van der Merwe
  • Computer applications in the biosciences : CABIOS , 12/ 1986 , Volume 2 , Issue 4 , pages: 243-249 , PubMed ID: 3450367
Contributors
Submitter of the first revision: Kieran Smallbone
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Kieran Smallbone

Metadata information

is (2 statements)
BioModels Database BIOMD0000000284
BioModels Database MODEL1010190003

isDescribedBy (1 statement)
PubMed 3450367

hasTaxon (1 statement)
Taxonomy Bacteria

isVersionOf (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources