François2005 - Mixed Feedback Loop (two-gene network)

Model Identifier
BIOMD0000000539
Short description
Paul François & Vincent Hakim. Core genetic module: the mixed feedback loop. Physical Review E 72, 3 Pt 1 (2005).

The so-called mixed feedback loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic networks. Here, we propose and mathematically study a model of the MFL and show that, by itself, it can serve both as a bistable switch and as a clock (an oscillator) depending on kinetic parameters. The MFL phase diagram as well as a detailed description of the nonlinear oscillation regime are presented and some biological examples are discussed. The results emphasize the role of protein interactions in the function of genetic modules and the usefulness of modeling RNA dynamics explicitly.
Format
SBML (L3V1)
Related Publication
  • Core genetic module: the mixed feedback loop.
  • Paul François, Vincent Hakim
  • Physical review. E, Statistical, nonlinear, and soft matter physics , 9/ 2005 , Volume 72 , Issue 3 Pt 1 , pages: 031908 , PubMed ID: 16241483
Contributors
Submitter of the first revision: Nicolas Le Novère
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: administrator, Nicolas Le Novère

Metadata information

is (2 statements)
BioModels Database BIOMD0000000539
BioModels Database MODEL1408130000

isDescribedBy (1 statement)
PubMed 16241483

hasTaxon (1 statement)
isVersionOf (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources