Wajima2009_BloodCoagulation_warfarin_heparin

View the 2011-07 Model of the Month entry for this model
Model Identifier
BIOMD0000000340
Short description

This model is from the article:
A comprehensive model for the humoral coagulation network in humans.
Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeuticsVolume 86, Issue 3, 10 June 2009, EPub 19516255,
Abstract:
Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.

Format
SBML (L2V4)
Related Publication
  • A comprehensive model for the humoral coagulation network in humans.
  • T Wajima, G K Isbister, S B Duffull
  • Clinical pharmacology and therapeutics , 9/ 2009 , Volume 86 , Issue 3 , pages: 290-298 , PubMed ID: 19516255
Contributors
Submitter of the first revision: Michael Schubert
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Michael Schubert

Metadata information

isDerivedFrom (13 statements)
PubMed 9645916
BioModels Database BIOMD0000000365
BioModels Database MODEL1108260015
BioModels Database MODEL1109160000
BioModels Database MODEL1109160001
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is (2 statements)
BioModels Database BIOMD0000000340
BioModels Database MODEL1107010002

isDescribedBy (1 statement)
PubMed 19516255

hasTaxon (1 statement)
Taxonomy Homo sapiens

encodes (1 statement)
hasVersion (1 statement)
Human Disease Ontology hemophilia B

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources