Metabolic control analysis (MCA) is a biochemical formalism, defining how variables, such as fluxes and concentrations, depend on network parameters. In this paper, owing to its limitations, it is shown with three example models (MODEL1305030000-2) that the algorithm with slight modification can be applied to all models.
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Abstract:
Metabolic control analysis is a biochemical formalism defined by Kacser and Burns in 1973, and given firm mathematical basis by Reder in 1988. The algorithm defined by Reder for calculating the control matrices is still used by software programs today, but is only valid for some biochemical models. We show that, with slight modification, the algorithm may be applied to all models.
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Metabolic Control Analysis: Rereading Reder
- Kieran Smallbone
- Quantitative Methods , 10/ 2013 , DOI: 10.48550/arXiv.1305.6449
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Kieran Smallbone
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