This model is described in the article:
Abstract:
Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian species, particularly mice, which exhibit significantly faster signaling dynamics. In this work, we present an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse. We demonstrate the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Finally, we employ the model to highlight a likely unknown mechanism related to the interaction between rhodopsin and rhodopsin kinase.
This model is hosted on BioModels Database and identified by: BIOMD0000000578.
To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
-
A comprehensive model of the phototransduction cascade in mouse rod cells.
- Brandon M Invergo, Daniele Dell'Orco, Ludovica Montanucci, Karl-Wilhelm Koch, Jaume Bertranpetit
- Molecular bioSystems , 6/ 2014 , Volume 10 , Issue 6 , pages: 1481-1489 , PubMed ID: 24675755
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Brandon Invergo
Metadata information
isDescribedBy (1 statement)
isDerivedFrom (1 statement)
hasTaxon (1 statement)
isVersionOf (1 statement)
occursIn (1 statement)
hasProperty (1 statement)
Connected external resources
SBGN view in Newt Editor
