Triggers: The Global Quantities contain triggers that allow one to change coupling settings, Salicyclic acid (SA) treatment and npr1 mutants.
LHY_on: true->NPR1 couples to LHY
PRR7_on: true->NPR1 couples to PRR7
WT: true->WT plants, false->npr1 mutant plants
SA: true->SA treated plants, false->no treatment
This model has L=1, i.e. operates only under constant light conditions and is not aiming to make preditions under diurnal conditions. Due to period overshoot only time points after 28h are relevant.
This model is described in the article:
Abstract:
Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. It has been hypothesized that the redox rhythm is linked to the circadian clock, but the mechanism and the biological significance of this link have only begun to be investigated. Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. Surprisingly, acute perturbation in the redox status triggered by the immune signal salicylic acid does not compromise the circadian clock but rather leads to its reinforcement. Mathematical modelling and subsequent experiments show that NPR1 reinforces the circadian clock without changing the period by regulating both the morning and the evening clock genes. This balanced network architecture helps plants gate their immune responses towards the morning and minimize costs on growth at night. Our study demonstrates how a sensitive redox rhythm interacts with a robust circadian clock to ensure proper responsiveness to environmental stimuli without compromising fitness of the organism.
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To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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Redox rhythm reinforces the circadian clock to gate immune response.
- Mian Zhou, Wei Wang, Sargis Karapetyan, Musoki Mwimba, Jorge Marqués, Nicolas E Buchler, Xinnian Dong
- Nature , 7/ 2015 , Volume 523 , Issue 7561 , pages: 472-476 , PubMed ID: 26098366
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: administrator, Sargis Karapetyan
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