This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Dimethyl sulfone
- DrugBank Accession Number
- DB14090
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Structure
Structure for Dimethyl sulfone (DB14090)
- Weight
- Average: 94.133
Monoisotopic: 94.008850126 - Chemical Formula
- C2H6O2S
- Synonyms
- Dimethyl sulphone
- Methyl sulfone
- Methylsulfonyl methane
- Methylsulfonylmethane
- MSM
- Sulfonylbismethane
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for symptomatic treatment of Osteoarthritis of the knee Combination Product in combination with: Chondroitin sulfate (DB09301), Glucosamine (DB01296) ••• ••• ••••••• ••• ••••••••• ••••••• ••••••• ••••••• Treatment of Pain, inflammatory ••• ••• •••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Dpheal Sul 16 Hot Gel 10.0 g/100mL Topical MSMINERAL CO.,Ltd. 2021-11-01 Not applicable US 
Msm Tablet 0.51 g/0.51g Oral Inc MBG 2019-01-24 Not applicable US MSM2000 Premium Tablet 500 mg/506mg Oral Vigen medical 2021-12-01 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Conart-MSM Sachet for Oral Solution Dimethyl sulfone (1500 mg) + Chondroitin sulfate (1200 mg) + Glucosamine sulfate (1500 mg) Powder, for solution Oral AV MANUFACTURING SDN.BHD 2020-09-08 Not applicable Malaysia 
Condrosa-MSM Sachet for Oral Solution Dimethyl sulfone (1500 mg) + Chondroitin sulfate (bovine) (1200 mg) + Glucosamine sulfate (1500 mg) Powder Oral AV MANUFACTURING SDN.BHD 2020-09-08 Not applicable Malaysia Cosamine Plus Forte M Powder Dimethyl sulfone (300 mg) + Chondroitin sulfate (400 mg) + Glucosamine hydrochloride (472 mg) Powder, for solution Oral Hovid Berhad 2020-09-08 Not applicable Malaysia DOCTOR HOYS Arnica Boost Dimethyl sulfone (2 g/1mL) + Arnica montana flower (5 g/1mL) Cream Topical Doctor Hoy's, Llc 2013-08-01 2019-07-18 US Donna Gluco-C Plus MSM Capsule Dimethyl sulfone (150 mg) + Chondroitin sulfate (100 mg) + Glucosamine (250 mg) Capsule Oral Duopharma Marketing Sdn. Bhd. 2020-09-08 Not applicable Malaysia - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DOCTOR HOYS Arnica Boost Dimethyl sulfone (2 g/1mL) + Arnica montana flower (5 g/1mL) Cream Topical Doctor Hoy's, Llc 2013-08-01 2019-07-18 US Dpheal Sul 16 Cool Dimethyl sulfone (0.02 g/100mL) + Menthol (3.65 g/100mL) Gel Topical MSMINERAL CO.,Ltd. 2021-11-01 Not applicable US Dpheal Sul 16 Hot Dimethyl sulfone (10.0 g/100mL) Gel Topical MSMINERAL CO.,Ltd. 2021-11-01 Not applicable US Goodoh EnergyCream Dimethyl sulfone (1 g/100mL) + N-Acetylglucosamine (1 g/100mL) Cream Topical PowerfulX 2021-05-24 Not applicable US IMPLAHeal P.OCream Dimethyl sulfone (1 g/100mL) + N-Acetylglucosamine (2 g/100mL) Cream Topical Threedayslove Co., Ltd. 2019-12-16 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as sulfones. These are compounds containing a sulfonyl group( which as the general structure RS(=O)2R' (R,R' =alkyl, aryl)) attached to two carbon atoms.
- Kingdom
- Organic compounds
- Super Class
- Organosulfur compounds
- Class
- Sulfonyls
- Sub Class
- Sulfones
- Direct Parent
- Sulfones
- Alternative Parents
- Organic oxides / Hydrocarbon derivatives
- Substituents
- Aliphatic acyclic compound / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Sulfone
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- sulfone (CHEBI:9349) / a sulfone (CPD-10437)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9H4PO4Z4FT
- CAS number
- 67-71-0
- InChI Key
- HHVIBTZHLRERCL-UHFFFAOYSA-N
- InChI
- InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
- IUPAC Name
- methanesulfonylmethane
- SMILES
- CS(C)(=O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0004983
- KEGG Compound
- C11142
- ChemSpider
- 5978
- BindingDB
- 50026473
- 23247
- ChEBI
- 9349
- ChEMBL
- CHEMBL25028
- ZINC
- ZINC000004658606
- Wikipedia
- Methylsulfonylmethane
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Back Pain Lower Back 1 1 Unknown Status Supportive Care Osteoarthritis (OA) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Cream Topical Gel Topical Gel Topical 10.0 g/100mL Capsule Oral Tablet Oral 500 mg Tablet, effervescent Oral Powder Oral Tablet Oral Tablet, film coated Capsule, coated Oral Tablet Oral Tablet Oral 0.51 g/0.51g Tablet Oral 500 mg/506mg Tablet, delayed release Oral Powder, for solution Oral Lotion Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 55.8 mg/mL ALOGPS logP -0.95 ALOGPS logP -1.3 Chemaxon logS -0.23 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 34.14 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 20.53 m3·mol-1 Chemaxon Polarizability 8.6 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 106.9198157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9157157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9206157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9079157 predictedDarkChem Lite v0.1.0 [M-H]- 123.98776 predictedDeepCCS 1.0 (2019) [M-H]- 106.9198157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9157157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9206157 predictedDarkChem Lite v0.1.0 [M-H]- 106.9079157 predictedDarkChem Lite v0.1.0 [M-H]- 123.98776 predictedDeepCCS 1.0 (2019) [M+H]+ 108.2282157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.2922157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.1483157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.2046157 predictedDarkChem Lite v0.1.0 [M+H]+ 126.785225 predictedDeepCCS 1.0 (2019) [M+H]+ 108.2282157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.2922157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.1483157 predictedDarkChem Lite v0.1.0 [M+H]+ 108.2046157 predictedDarkChem Lite v0.1.0 [M+H]+ 126.785225 predictedDeepCCS 1.0 (2019) [M+Na]+ 107.1897157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.1648157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.2579157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.2799157 predictedDarkChem Lite v0.1.0 [M+Na]+ 134.91058 predictedDeepCCS 1.0 (2019) [M+Na]+ 107.1897157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.1648157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.2579157 predictedDarkChem Lite v0.1.0 [M+Na]+ 107.2799157 predictedDarkChem Lite v0.1.0 [M+Na]+ 134.91058 predictedDeepCCS 1.0 (2019)
Drug created at June 18, 2018 16:42 / Updated at April 01, 2022 19:23