DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]

LSD1, MEC2, SPK1

Chromosome XVI: 261,727-264,192 reverse strand.

This transcript has 1 exon, is annotated with 31 domains and features, is associated with 41 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YPL153C Show transcript tableHide transcript table