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Symbol report for CDS2

HGNC data for CDS2

Approved symbol
CDS2
Approved name

CDP-diacylglycerol synthase 2

Locus type
gene with protein product
HGNC ID
HGNC:1801
Symbol status
Approved
Alias names
phosphatidate cytidylyltransferase 2
Chromosomal location
20p12.3
UCSC
Alliance of Genome Resources
Bos taurus
CDS2 VGNC:27156 VGNC
Canis familiaris
CDS2 VGNC:39081 VGNC
Equus caballus
CDS2 VGNC:51520 VGNC
Felis catus
CDS2 VGNC:60720 VGNC
Macaca mulatta
CDS2 VGNC:70995 VGNC
Mus musculus
Cds2 MGI:1332236 Curated
Pan troglodytes
CDS2 VGNC:6075 VGNC
Rattus norvegicus
Cds2 RGD:621186
Sus scrofa
CDS2 VGNC:95869 VGNC
Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.
Volta M et al. Genomics 1999 Jan;55(1)68-77
Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B.
Genomics 1999 Jan;55(1)68-77
Abstract: The general strategies of phototransduction in vertebrates and invertebrates share many similarities, but differ significantly in their underlying molecular machinery. The CDS gene encodes the CDP-diacylglycerol synthase (CDS) enzyme and is required for phototransduction in Drosophila. Using a bioinformatic approach, we have identified two novel transcripts (CDS1 and CDS2) highly homologous to the Drosophila CDS gene. We isolated and sequenced the CDS2 full-length cDNA and mapped the two genes to human chromosomes 20p13 (CDS2) and 4q21.1 (CDS1). Sequence analysis revealed that both genes are highly homologous to the Drosophila protein (64.4 and 58. 6% identity at the protein level between CDS and CDS2 and between CDS and CDS1, respectively). The mouse homologs for both genes were isolated and used in RNA in situ hybridization studies on adult and embryonic mouse tissue sections. These studies showed that Cds2 is highly expressed in the differentiating neuroblasts of the neural retina and in the central nervous system during embryonic development, while it was not detected in adult retina. Cds1, on the other hand, shows a high level of expression in the photoreceptor layer of adult retina, which strongly suggests a role for Cds1 in phototransduction. Knowledge of the expression pattern of these genes in mammals may shed light on the evolution of vision mechanisms and help in the evaluation of candidate genes for human retinopathies.
Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.
Halford S et al. Genomics 1998 Nov;54(1)140-144
Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM.
Genomics 1998 Nov;54(1)140-144
Abstract: Phototransduction in Drosophila is a phosphoinositide-mediated signaling pathway. Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a central role in this process, and its levels are tightly regulated. A photoreceptor-specific form of the enzyme CDP-diacylglycerol synthase (CDS), which catalyzes the formation of CDP-diacylglycerol from phosphatidic acid, is a key regulator of the amount of PIP2 available for signaling. cds mutants develop light-induced retinal degeneration. As part of a search for novel genes that may be involved in eye disease in human, using Drosophila phototransduction genes as a model system, two human CDP-diacylglycerol synthase genes (CDS1 and CDS2) were cloned and sequenced. Radiation hybrid panel mapping and fluorescence in situ hybridization were used to localize the genes to chromosomes 4q21 and 20p13. As yet, no known retinal diseases map to either of these regions.