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Acute myeloid leukemia with minimal differentiation

MedGen UID:
101100
•Concept ID:
C0522631
•
Neoplastic Process
Synonyms: Acute granulocytic leukemia, minimal differentiation; acute myeloblastic leukaemia with minimal differentiation; Acute myeloblastic leukemia; Acute Myeloblastic Leukemia with Minimal Differentiation; acute myeloblastic leukemia with minimal differentiation; Acute myeloblastic leukemia, minimal differentiation; Acute Myeloblastic Leukemia, Minimally Differentiated; acute myeloblastic leukemia, minimally differentiated; acute myelocytic leukaemia with minimal differentiation; acute myelocytic leukemia with minimal differentiation; Acute myelocytic leukemia, minimal differentiation; acute myelogenous leukaemia with minimal differentiation; Acute Myelogenous Leukemia with Minimal Differentiation; acute myelogenous leukemia with minimal differentiation; Acute myelogenous leukemia, minimal differentiation; acute myeloid leukaemia with minimal differentiation (MO); Acute Myeloid Leukemia with Minimal Differentiation; acute myeloid leukemia with minimal differentiation; Acute Myeloid Leukemia with Minimal Differentiation (MO); acute myeloid leukemia with minimal differentiation (MO); Acute Myeloid Leukemia, Minimally Differentiated; acute myeloid leukemia, minimally differentiated; AML M0; AML with Minimal Differentiation; AML with minimal differentiation; AMLMD; FAB M0; M0 acute granulocytic leukaemia; M0 acute granulocytic leukaemia with minimal differentiation; M0 acute granulocytic leukemia; M0 acute granulocytic leukemia with minimal differentiation; M0 acute myeloblastic leukaemia; M0 Acute Myeloblastic Leukemia; M0 acute myeloblastic leukemia; M0 acute myelocytic leukaemia; M0 acute myelocytic leukemia; M0 acute myelogenous leukaemia; M0 acute myelogenous leukaemia with minimal differentiation; M0 Acute Myelogenous Leukemia; M0 acute myelogenous leukemia; M0 Acute Myelogenous Leukemia with Minimal Differentiation; M0 acute myelogenous leukemia with minimal differentiation; M0 myeloid leukaemia; M0 myeloid leukaemia with minimal differentiation; M0 Myeloid Leukemia; M0 myeloid leukemia; M0 Myeloid Leukemia with Minimal Differentiation; M0 myeloid leukemia with minimal differentiation; minimally differentiated acute myeloblastic leukaemia; Minimally differentiated acute myeloblastic leukemia; minimally differentiated acute myeloblastic leukemia
SNOMED CT: Acute myeloblastic leukemia, minimal differentiation (103689001); Acute granulocytic leukemia, minimal differentiation (103689001); Acute myelogenous leukemia, minimal differentiation (103689001); Acute myelocytic leukemia, minimal differentiation (103689001); FAB M0 (103689001); Acute myeloblastic leukemia (103689001); Acute myeloid leukemia with minimal differentiation (103689001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005223
Orphanet: ORPHA98832

Definition

A rare subtype of acute myeloid leukemia characterized by clonal proliferation of poorly differentiated myeloid blasts in the bone marrow, blood or other tissues. It usually presents with anemia, thrombocytopenia and other nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). Low remission rates are reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia with minimal differentiation

Professional guidelines

PubMed

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner C, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C, Kobold S
Nat Biotechnol 2023 Nov;41(11):1618-1632. Epub 2023 Mar 13 doi: 10.1038/s41587-023-01684-0. PMID: 36914885Free PMC Article
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Multiparameter flow cytometry in the diagnosis and management of acute leukemia.
Peters JM, Ansari MQ
Arch Pathol Lab Med 2011 Jan;135(1):44-54. doi: 10.5858/2010-0387-RAR.1. PMID: 21204710

Recent clinical studies

Etiology

Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group.
Weinberg OK, Hasserjian RP, Baraban E, Ok CY, Geyer JT, Philip JKSS, Kurzer JH, Rogers HJ, Nardi V, Stone RM, Garcia JS, Hsi ED, Bagg A, Wang SA, Orazi A, Arber DA
Mod Pathol 2019 Sep;32(9):1373-1385. Epub 2019 Apr 18 doi: 10.1038/s41379-019-0263-3. PMID: 31000771
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.
Patel KP, Khokhar FA, Muzzafar T, James You M, Bueso-Ramos CE, Ravandi F, Pierce S, Medeiros LJ
Mod Pathol 2013 Feb;26(2):195-203. Epub 2012 Aug 31 doi: 10.1038/modpathol.2012.142. PMID: 22936064Free PMC Article

Diagnosis

Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group.
Weinberg OK, Hasserjian RP, Baraban E, Ok CY, Geyer JT, Philip JKSS, Kurzer JH, Rogers HJ, Nardi V, Stone RM, Garcia JS, Hsi ED, Bagg A, Wang SA, Orazi A, Arber DA
Mod Pathol 2019 Sep;32(9):1373-1385. Epub 2019 Apr 18 doi: 10.1038/s41379-019-0263-3. PMID: 31000771
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia.
Shanmugam V, Dorfman DM
Am J Hematol 2019 Aug;94(8):955-956. Epub 2018 Dec 5 doi: 10.1002/ajh.25354. PMID: 30431665
Acute leukemias of ambiguous origin.
Porwit A, Béné MC
Am J Clin Pathol 2015 Sep;144(3):361-76. doi: 10.1309/AJCPSTU55DRQEGTE. PMID: 26276768
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.
Patel KP, Khokhar FA, Muzzafar T, James You M, Bueso-Ramos CE, Ravandi F, Pierce S, Medeiros LJ
Mod Pathol 2013 Feb;26(2):195-203. Epub 2012 Aug 31 doi: 10.1038/modpathol.2012.142. PMID: 22936064Free PMC Article

Therapy

Translocations between the long arms of chromosomes 1 and 5 in hematologic malignancies are strongly associated with neoplasms of the myeloid lineages.
Johansson B, Brøndum-Nielsen K, Billström R, Schiødt I, Mitelman F
Cancer Genet Cytogenet 1997 Dec;99(2):97-101. doi: 10.1016/s0165-4608(97)00198-2. PMID: 9398862

Prognosis

Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group.
Weinberg OK, Hasserjian RP, Baraban E, Ok CY, Geyer JT, Philip JKSS, Kurzer JH, Rogers HJ, Nardi V, Stone RM, Garcia JS, Hsi ED, Bagg A, Wang SA, Orazi A, Arber DA
Mod Pathol 2019 Sep;32(9):1373-1385. Epub 2019 Apr 18 doi: 10.1038/s41379-019-0263-3. PMID: 31000771
TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.
Patel KP, Khokhar FA, Muzzafar T, James You M, Bueso-Ramos CE, Ravandi F, Pierce S, Medeiros LJ
Mod Pathol 2013 Feb;26(2):195-203. Epub 2012 Aug 31 doi: 10.1038/modpathol.2012.142. PMID: 22936064Free PMC Article
Acute myeloid leukemia with minimal differentiation. A multiple parameter study.
Cohen PL, Hoyer JD, Kurtin PJ, Dewald GW, Hanson CA
Am J Clin Pathol 1998 Jan;109(1):32-8. doi: 10.1093/ajcp/109.1.32. PMID: 9426515
Translocations between the long arms of chromosomes 1 and 5 in hematologic malignancies are strongly associated with neoplasms of the myeloid lineages.
Johansson B, Brøndum-Nielsen K, Billström R, Schiødt I, Mitelman F
Cancer Genet Cytogenet 1997 Dec;99(2):97-101. doi: 10.1016/s0165-4608(97)00198-2. PMID: 9398862

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