U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tongue cancer

MedGen UID:
102262
•Concept ID:
C0153349
•
Neoplastic Process
Synonyms: Cancer of the Tongue; Cancer of Tongue; Cancer, Tongue; Cancers, Tongue; Tongue Cancer; Tongue Cancers
SNOMED CT: CA - Cancer of tongue (363375006); Cancer of tongue (363375006); Malignant tumor of tongue (363375006)
 
Monarch Initiative: MONDO:0004631

Definition

A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. [from NCI]

Professional guidelines

PubMed

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607
Screening, diagnosis, and treatment of cancer in long-term dialysis patients.
Holley JL
Clin J Am Soc Nephrol 2007 May;2(3):604-10. Epub 2007 Mar 14 doi: 10.2215/CJN.03931106. PMID: 17699470

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Tongue cancer treatment and oncological outcomes: The role of glossectomy classification.
De Berardinis R, Tagliabue M, Belloni P, Gandini S, Scaglione D, Maffini F, Margherini S, Riccio S, Giugliano G, Bruschini R, Chu F, Ansarin M
Surg Oncol 2022 Jun;42:101751. Epub 2022 Apr 6 doi: 10.1016/j.suronc.2022.101751. PMID: 35447523
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Tongue cancer during pregnancy: Surgery and more, a multidisciplinary challenge.
Tagliabue M, Elrefaey SH, Peccatori F, Favia G, Navach V, Pignataro L, Capaccio P, Venturino M, Tredici S, Alterio D, Mosca F, Pugni L, Scarfone G, Cossu Rocca M, Calabrese L
Crit Rev Oncol Hematol 2016 Feb;98:1-11. Epub 2015 Oct 9 doi: 10.1016/j.critrevonc.2015.09.006. PMID: 26476748
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article

Diagnosis

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
He Y, Huang C, Cai K, Liu P, Chen X, Xu YI, Ming Z, Liu Q, Xie Q, Xia X, Sun Y, Luo J, Wei R
Acta Biochim Biophys Sin (Shanghai) 2021 Jul 5;53(7):893-902. doi: 10.1093/abbs/gmab059. PMID: 33954334
Contemplating Resectability.
Shuman AG
Hastings Cent Rep 2017 Nov;47(6):3-4. doi: 10.1002/hast.777. PMID: 29171050

Therapy

Brachytherapy and osteoradionecrosis in patients with base of tongue cancer.
Danielsson D, Hagel E, Dybeck-Udd S, Sjöström M, Kjeller G, Bengtsson M, Abtahi J, von Beckerath M, Thor A, Halle M, Friesland S, Mercke C, Westermark A, Högmo A, Munck-Wikland E
Acta Otolaryngol 2023 Jan;143(1):77-84. Epub 2023 Jan 3 doi: 10.1080/00016489.2022.2161627. PMID: 36595465
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Effects of flavonoids on tongue squamous cell carcinoma.
Gutiérrez-Venegas G, Sánchez-Carballido MA, Delmas Suárez C, Gómez-Mora JA, Bonneau N
Cell Biol Int 2020 Mar;44(3):686-720. Epub 2019 Dec 4 doi: 10.1002/cbin.11266. PMID: 31758641
Mechanisms correlated with chemotherapy resistance in tongue cancers.
Han G, Xu C, Yu D
J Cancer Res Ther 2018 Jan;14(1):1-5. doi: 10.4103/jcrt.JCRT_763_17. PMID: 29516950

Prognosis

Tongue cancer treatment and oncological outcomes: The role of glossectomy classification.
De Berardinis R, Tagliabue M, Belloni P, Gandini S, Scaglione D, Maffini F, Margherini S, Riccio S, Giugliano G, Bruschini R, Chu F, Ansarin M
Surg Oncol 2022 Jun;42:101751. Epub 2022 Apr 6 doi: 10.1016/j.suronc.2022.101751. PMID: 35447523
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
He Y, Huang C, Cai K, Liu P, Chen X, Xu YI, Ming Z, Liu Q, Xie Q, Xia X, Sun Y, Luo J, Wei R
Acta Biochim Biophys Sin (Shanghai) 2021 Jul 5;53(7):893-902. doi: 10.1093/abbs/gmab059. PMID: 33954334
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Mechanisms correlated with chemotherapy resistance in tongue cancers.
Han G, Xu C, Yu D
J Cancer Res Ther 2018 Jan;14(1):1-5. doi: 10.4103/jcrt.JCRT_763_17. PMID: 29516950

Clinical prediction guides

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.
Tota JE, Engels EA, Lingen MW, Agrawal N, Kerr AR, Zumsteg ZS, Cheung LC, Katki HA, Abnet CC, Chaturvedi AK
J Clin Oncol 2024 May 20;42(15):1745-1753. Epub 2023 Nov 30 doi: 10.1200/JCO.23.00729. PMID: 38033283Free PMC Article
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion.
Gan RH, Wei H, Xie J, Zheng DP, Luo EL, Huang XY, Xie J, Zhao Y, Ding LC, Su BH, Lin LS, Zheng DL, Lu YG
Cell Cycle 2018;17(2):216-224. Epub 2017 Dec 21 doi: 10.1080/15384101.2017.1395534. PMID: 29117785Free PMC Article
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article
Biomarkers in tongue cancer: understanding the molecular basis and their clinical implications.
Zheng M, Li L, Tang YL, Liang XH
Postgrad Med J 2010 May;86(1015):292-8. Epub 2010 Apr 14 doi: 10.1136/pgmj.2009.086504. PMID: 20392934

Recent systematic reviews

Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Functional considerations between flap and non-flap reconstruction in oral tongue cancer: A systematic review.
Cortina LE, Moverman DJ, Zhao Y, Goss D, Zenga J, Puram SV, Varvares MA
Oral Oncol 2023 Dec;147:106596. Epub 2023 Oct 13 doi: 10.1016/j.oraloncology.2023.106596. PMID: 37839153
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.
Elseragy A, Bello IO, Wahab A, Coletta RD, Mäkitie AA, Leivo I, Almangush A, Salo T
Head Neck 2022 Jun;44(6):1481-1491. Epub 2022 Feb 28 doi: 10.1002/hed.27022. PMID: 35229398Free PMC Article
Speech and swallowing following tongue cancer surgery and free flap reconstruction--a systematic review.
Lam L, Samman N
Oral Oncol 2013 Jun;49(6):507-24. Epub 2013 Apr 6 doi: 10.1016/j.oraloncology.2013.03.001. PMID: 23566773

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...