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Malignant Exocervical Neoplasm

MedGen UID:
102275
•Concept ID:
C0153570
•
Neoplastic Process
Synonyms: Cancer of exocervix; Malignant Exocervical Tumor; Malignant Exocervix Neoplasm; Malignant Exocervix Tumor; Malignant neoplasm of exocervix; Malignant Neoplasm of Exocervix; Malignant Neoplasm of the Exocervix; Malignant Neoplasm of the Uterine Exocervix; Malignant Neoplasm of Uterine Exocervix; Malignant Tumor of Exocervix; Malignant Tumor of the Exocervix; Malignant Tumor of the Uterine Exocervix; Malignant Tumor of Uterine Exocervix; Malignant Uterine Exocervix Neoplasm; Malignant Uterine Exocervix Tumor
SNOMED CT: Malignant neoplasm of exocervix (372099007); Cancer of exocervix (372099007)

Definition

A malignant neoplasm that affects the exocervix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Exocervical Neoplasm

Professional guidelines

PubMed

Human papilloma virus risk factors for infection and genotype distribution in aboriginal women from Northern Argentina.
Deluca GD, Basiletti J, González JV, Díaz Vásquez N, Lucero RH, Picconi MA
Medicina (B Aires) 2012;72(6):461-6. PMID: 23241287
HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma.
Cappello F
Gynecol Oncol 2003 Dec;91(3):661. doi: 10.1016/j.ygyno.2003.08.009. PMID: 14675699
Diagnosis, treatment and follow-up of H.P.V.-C.I.N.
Mateos Burguillo JF, Rodriguez Zarauz R, Uguet de Resayre C, Bajo Arenas JM
Eur J Gynaecol Oncol 1995;16(1):48-53. PMID: 7744116

Recent clinical studies

Etiology

Risk of second primary cutaneous and noncutaneous melanoma after cutaneous melanoma diagnosis: A population-based study.
Beroukhim K, Pourang A, Eisen DB
J Am Acad Dermatol 2020 Mar;82(3):683-689. Epub 2019 Oct 15 doi: 10.1016/j.jaad.2019.10.024. PMID: 31626886
Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.
Diedrich JT, Felix JC, Lonky NM
J Low Genit Tract Dis 2016 Jan;20(1):52-6. doi: 10.1097/LGT.0b013e3182a5296e. PMID: 24477170
Atypical Papanicolaou smear in pregnancy.
Connolly TP, Evans AC
Clin Med Res 2005 Feb;3(1):13-8. doi: 10.3121/cmr.3.1.13. PMID: 15962016Free PMC Article
Pure cutting current for loop excision of squamous intraepithelial lesions.
McLucas B, McGill J
J Reprod Med 1994 May;39(5):373-6. PMID: 8064704
Cytochemistry and ultrastructure of normal and neoplastic cells exfoliated from the human uterine cervix.
Concha M, Caorsi I, Rodríguez EM
Ultrastruct Pathol 1986;10(1):23-38. doi: 10.3109/01913128609015560. PMID: 3961921

Diagnosis

Fractal geometry applied to the analysis of cervix biopsy.
Rodríguez-Velásquez JO, Barrios-Arroyave FA, Correa-Herrera SC, Grisales-Gutiérrez CE, Prieto-Bohórquez SE, Jattin-Balcázar JJ, Ruiz-Morales JJ
Diagn Cytopathol 2021 Aug;49(8):938-943. Epub 2021 May 6 doi: 10.1002/dc.24762. PMID: 33955721
Risk of second primary cutaneous and noncutaneous melanoma after cutaneous melanoma diagnosis: A population-based study.
Beroukhim K, Pourang A, Eisen DB
J Am Acad Dermatol 2020 Mar;82(3):683-689. Epub 2019 Oct 15 doi: 10.1016/j.jaad.2019.10.024. PMID: 31626886
Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.
Diedrich JT, Felix JC, Lonky NM
J Low Genit Tract Dis 2016 Jan;20(1):52-6. doi: 10.1097/LGT.0b013e3182a5296e. PMID: 24477170
Atypical Papanicolaou smear in pregnancy.
Connolly TP, Evans AC
Clin Med Res 2005 Feb;3(1):13-8. doi: 10.3121/cmr.3.1.13. PMID: 15962016Free PMC Article
E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.
Carico E, Atlante M, Bucci B, Nofroni I, Vecchione A
Gynecol Oncol 2001 Feb;80(2):156-61. doi: 10.1006/gyno.2000.6035. PMID: 11161853

Therapy

Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.
Diedrich JT, Felix JC, Lonky NM
J Low Genit Tract Dis 2016 Jan;20(1):52-6. doi: 10.1097/LGT.0b013e3182a5296e. PMID: 24477170
Hsp60 and Hspl0 as antitumor molecular agents.
Cappello F, Czarnecka AM, La Rocca G, Di Stefano A, Zummo G, Macario AJ
Cancer Biol Ther 2007 Apr;6(4):487-9. doi: 10.4161/cbt.6.4.4087. PMID: 17457039
E-cadherin-dependent adhesion of dendritic and Langerhans cells to keratinocytes is defective in cervical human papillomavirus-associated (pre)neoplastic lesions.
Hubert P, Caberg JH, Gilles C, Bousarghin L, Franzen-Detrooz E, Boniver J, Delvenne P
J Pathol 2005 Jul;206(3):346-55. doi: 10.1002/path.1771. PMID: 15852499
Treatment of cervix condylomata with alpha-IFN leucocytar.
Zarcone R, Bellini P, Cardone G, Cardone A
Clin Exp Obstet Gynecol 1995;22(4):326-9. PMID: 8777789
Pure cutting current for loop excision of squamous intraepithelial lesions.
McLucas B, McGill J
J Reprod Med 1994 May;39(5):373-6. PMID: 8064704

Prognosis

Risk of second primary cutaneous and noncutaneous melanoma after cutaneous melanoma diagnosis: A population-based study.
Beroukhim K, Pourang A, Eisen DB
J Am Acad Dermatol 2020 Mar;82(3):683-689. Epub 2019 Oct 15 doi: 10.1016/j.jaad.2019.10.024. PMID: 31626886
Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma.
Aviel-Ronen S, Rubinek T, Zadok O, Vituri A, Avivi C, Wolf I, Barshack I
J Clin Pathol 2016 Jan;69(1):53-7. Epub 2015 Jul 24 doi: 10.1136/jclinpath-2015-202929. PMID: 26209729
Expression of 60-kD heat shock protein increases during carcinogenesis in the uterine exocervix.
Cappello F, Bellafiore M, Palma A, Marciano V, Martorana G, Belfiore P, Martorana A, Farina F, Zummo G, Bucchieri F
Pathobiology 2002-2003;70(2):83-8. doi: 10.1159/000067304. PMID: 12476033
Positive margins after conization and risk of persistent lesion.
Narducci F, Occelli B, Boman F, Vinatier D, Leroy JL
Gynecol Oncol 2000 Mar;76(3):311-4. doi: 10.1006/gyno.1999.5697. PMID: 10684702
Pure cutting current for loop excision of squamous intraepithelial lesions.
McLucas B, McGill J
J Reprod Med 1994 May;39(5):373-6. PMID: 8064704

Clinical prediction guides

Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma.
Aviel-Ronen S, Rubinek T, Zadok O, Vituri A, Avivi C, Wolf I, Barshack I
J Clin Pathol 2016 Jan;69(1):53-7. Epub 2015 Jul 24 doi: 10.1136/jclinpath-2015-202929. PMID: 26209729
Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.
Diedrich JT, Felix JC, Lonky NM
J Low Genit Tract Dis 2016 Jan;20(1):52-6. doi: 10.1097/LGT.0b013e3182a5296e. PMID: 24477170
E-cadherin-dependent adhesion of dendritic and Langerhans cells to keratinocytes is defective in cervical human papillomavirus-associated (pre)neoplastic lesions.
Hubert P, Caberg JH, Gilles C, Bousarghin L, Franzen-Detrooz E, Boniver J, Delvenne P
J Pathol 2005 Jul;206(3):346-55. doi: 10.1002/path.1771. PMID: 15852499
Positive margins after conization and risk of persistent lesion.
Narducci F, Occelli B, Boman F, Vinatier D, Leroy JL
Gynecol Oncol 2000 Mar;76(3):311-4. doi: 10.1006/gyno.1999.5697. PMID: 10684702
Cytokeratins of normal epithelia and some neoplasms of the female genital tract.
Moll R, Levy R, Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G, Franke WW
Lab Invest 1983 Nov;49(5):599-610. PMID: 6195450

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