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Allergic contact dermatitis

MedGen UID:
102474
•Concept ID:
C0162820
•
Disease or Syndrome
Synonyms: Allergic Contact Dermatitides; Allergic Contact Dermatitis; Allergic Eczematous Dermatitides; Allergic Eczematous Dermatitis; Contact Dermatitides, Allergic; Contact Dermatitis, Allergic; Dermatitides, Allergic Contact; Dermatitides, Allergic Eczematous; Dermatitis, Allergic Contact; Dermatitis, Allergic Eczematous; Dermatitis, Contact, Allergic; Eczematous Dermatitides, Allergic; Eczematous Dermatitis, Allergic
SNOMED CT: Allergic contact dermatitis (238575004); ACD - Allergic contact dermatitis (238575004)
 
Monarch Initiative: MONDO:0006525

Definition

An inflammatory skin condition caused by an immune response to direct contact between the skin and an allergen. It consists of a delayed type of allergic reaction at the affected site with resulting red, swollen, and blistered skin that may itch or leak. [from NCI]

Professional guidelines

PubMed

Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Contact Dermatitis: Classifications and Management.
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
Diagnosis and management of contact dermatitis.
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788

Recent clinical studies

Etiology

Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Patch Testing Pearls.
Uyesugi BA, Sheehan MP
Clin Rev Allergy Immunol 2019 Feb;56(1):110-118. doi: 10.1007/s12016-018-8715-y. PMID: 30269296
Alkyl Glucosides.
Alfalah M, Loranger C, Sasseville D
Dermatitis 2017 Jan/Feb;28(1):3-4. doi: 10.1097/DER.0000000000000234. PMID: 27775973
Allergic contact dermatitis: Patient diagnosis and evaluation.
Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B
J Am Acad Dermatol 2016 Jun;74(6):1029-40. doi: 10.1016/j.jaad.2015.02.1139. PMID: 27185421
Shellac.
Das S, Jacob SE
Dermatitis 2011 Jul-Aug;22(4):220-2. PMID: 21781639

Diagnosis

Allergic Contact Dermatitis.
Edwards TM, Usatine RP, Heath CR
Cutis 2023 Oct;112(4):195-197. doi: 10.12788/cutis.0868. PMID: 37988316
Allergic contact dermatitis.
Edwards TM, Usatine RP, Heath CR
J Fam Pract 2023 Oct;72(8):350-355. doi: 10.12788/jfp.0678. PMID: 37862625
Pediatric Allergic Contact Dermatitis.
Brown C, Yu J
Immunol Allergy Clin North Am 2021 Aug;41(3):393-408. Epub 2021 Jun 5 doi: 10.1016/j.iac.2021.04.004. PMID: 34225896
Allergic Contact Dermatitis.
Adler BL, DeLeo VA
JAMA Dermatol 2021 Mar 1;157(3):364. doi: 10.1001/jamadermatol.2020.5639. PMID: 33502447
Allergic Contact Dermatitis.
Nassau S, Fonacier L
Med Clin North Am 2020 Jan;104(1):61-76. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.012. PMID: 31757238

Therapy

Pediatric allergic contact dermatitis. Part 2: Patch testing series, procedure, and unique scenarios.
Neale H, Garza-Mayers AC, Tam I, Yu J
J Am Acad Dermatol 2021 Feb;84(2):247-255. Epub 2020 Nov 17 doi: 10.1016/j.jaad.2020.11.001. PMID: 33217511
Review of biologics in allergic contact dermatitis.
Bhatia J, Sarin A, Wollina U, Lotti T, Navarini AA, Mueller SM, Grabbe S, Saloga J, Rokni GR, Goldust M
Contact Dermatitis 2020 Sep;83(3):179-181. Epub 2020 Jun 17 doi: 10.1111/cod.13584. PMID: 32347968
Allergic Contact Dermatitis of the Vulva.
Woodruff CM, Trivedi MK, Botto N, Kornik R
Dermatitis 2018 Sep/Oct;29(5):233-243. doi: 10.1097/DER.0000000000000339. PMID: 30179968
Allergic contact dermatitis from ophthalmics.
Zheng Y, Chaudhari PR, Maibach HI
Cutan Ocul Toxicol 2017 Dec;36(4):317-320. Epub 2017 Mar 6 doi: 10.1080/15569527.2017.1295251. PMID: 28632093
Wound-Related Allergic/Irritant Contact Dermatitis.
Alavi A, Sibbald RG, Ladizinski B, Saraiya A, Lee KC, Skotnicki-Grant S, Maibach H
Adv Skin Wound Care 2016 Jun;29(6):278-86. doi: 10.1097/01.ASW.0000482834.94375.1e. PMID: 27171256

Prognosis

Occupational allergic contact dermatitis from systemic drugs.
Gilissen L, Boeckxstaens E, Geebelen J, Goossens A
Contact Dermatitis 2020 Jan;82(1):24-30. Epub 2019 Sep 1 doi: 10.1111/cod.13383. PMID: 31400016
Isothiazolinone derivatives and allergic contact dermatitis: a review and update.
Herman A, Aerts O, de Montjoye L, Tromme I, Goossens A, Baeck M
J Eur Acad Dermatol Venereol 2019 Feb;33(2):267-276. doi: 10.1111/jdv.15267. PMID: 30284765
Allergic contact dermatitis: Patient diagnosis and evaluation.
Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B
J Am Acad Dermatol 2016 Jun;74(6):1029-40. doi: 10.1016/j.jaad.2015.02.1139. PMID: 27185421
Diagnosis and management of contact dermatitis.
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788
Occupational dermatoses.
Beltrani VS
Curr Opin Allergy Clin Immunol 2003 Apr;3(2):115-23. doi: 10.1097/00130832-200304000-00005. PMID: 12750608

Clinical prediction guides

Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.
Pemberton MA, Kimber I
Regul Toxicol Pharmacol 2023 Feb;138:105341. Epub 2023 Jan 23 doi: 10.1016/j.yrtph.2023.105341. PMID: 36702195
Allergic contact dermatitis from dyes used in the temple of spectacles.
Ahrensbøll-Friis U, Simonsen AB, Dahlin J, Isaksson M, Zachariae C, Johansen JD
Contact Dermatitis 2022 Jan;86(1):25-28. Epub 2021 Oct 25 doi: 10.1111/cod.13989. PMID: 34655078
Textile and Shoe Allergic Contact Dermatitis in Military Personnel.
Slodownik D, Reiss A, Mashiach Y, Ingber A, Sprecher E, Moshe S
Dermatitis 2018 Jul/Aug;29(4):196-199. doi: 10.1097/DER.0000000000000390. PMID: 30024451
Conctact dermatitis: some important topics.
Pigatto PD
Eur Ann Allergy Clin Immunol 2015 Nov;47(6):188-91. PMID: 26549335
Tefillin dermatitis.
Trattner A, David M
J Am Acad Dermatol 2005 May;52(5):831-3. doi: 10.1016/j.jaad.2004.12.042. PMID: 15858473

Recent systematic reviews

Nipple eczema: A systematic review and practical recommendations.
Reynaert V, Gutermuth J, Wollenberg A
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1149-1159. Epub 2023 Feb 16 doi: 10.1111/jdv.18920. PMID: 36695082
Side effects of gel nail polish: A systematic review.
Litaiem N, Baklouti M, Zeglaoui F
Clin Dermatol 2022 Nov-Dec;40(6):706-715. Epub 2022 Jul 28 doi: 10.1016/j.clindermatol.2022.07.008. PMID: 35907576
Hand hygiene and hand eczema: A systematic review and meta-analysis.
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
Facial and neck erythema associated with dupilumab treatment: A systematic review.
Jo CE, Finstad A, Georgakopoulos JR, Piguet V, Yeung J, Drucker AM
J Am Acad Dermatol 2021 May;84(5):1339-1347. Epub 2021 Jan 8 doi: 10.1016/j.jaad.2021.01.012. PMID: 33428978

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