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Basal Cell Adenoma

MedGen UID:
104696
•Concept ID:
C0205646
•
Neoplastic Process
Synonyms: Adenoma, Basal Cell; Adenomas, Basal Cell; Basal Cell Adenomas
SNOMED CT: Basal cell adenoma (27230006)

Definition

A salivary gland benign epithelial neoplasm with a uniform, monomorphic appearance that is dominated by basal cells forming trabecular structures. It is rare and occurs mostly on the parotid gland. The average age of patients has been reported to be 58 years. Swelling is the most constant clinical finding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal Cell Adenoma

Professional guidelines

PubMed

The differential diagnosis of parotid gland tumors with high-resolution ultrasound in otolaryngological practice.
Rzepakowska A, Osuch-Wójcikiewicz E, Sobol M, Cruz R, Sielska-Badurek E, Niemczyk K
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3231-3240. Epub 2017 Jun 13 doi: 10.1007/s00405-017-4636-2. PMID: 28612315Free PMC Article
Classification and differential diagnosis of clear and basal cell tumors of the salivary glands.
Seifert G
Semin Diagn Pathol 1996 May;13(2):95-103. PMID: 8734415
Differential diagnosis of pleomorphic adenoma by immunohistochemical means.
Nishimura T, Furukawa M, Kawahara E, Miwa A
J Laryngol Otol 1991 Dec;105(12):1057-60. doi: 10.1017/s0022215100118183. PMID: 1664847

Recent clinical studies

Etiology

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Basal cell adenoma and pleomorphic adenoma of the parotid gland: a single center experience.
Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Basal cell adenocarcinoma of the parotid gland: Comparison with basal cell adenoma for preoperative diagnosis.
Terada T, Kawata R, Higashino M, Kurisu Y, Kuwabara H, Hirose Y
Auris Nasus Larynx 2021 Apr;48(2):310-316. Epub 2020 Sep 17 doi: 10.1016/j.anl.2020.08.024. PMID: 32950324
A retrospective study of 30 basal cell adenomas of the salivary gland in a Brazilian population and literature review.
Cordeiro MS, de Freitas Filho SAJ, Servato JPS, Eisenberg ALA, Dias FL, de Faria PR, Loyola AM, Cardoso SV
Eur Arch Otorhinolaryngol 2021 Jul;278(7):2447-2454. Epub 2020 Sep 4 doi: 10.1007/s00405-020-06331-x. PMID: 32886182
Basal cell adenoma of the parotid gland: clinical and pathological findings in 29 cases.
Lu J, Zhang W, Wang Z, Jia H, Ma Y, Wu H, Xiang M
Int J Clin Exp Pathol 2015;8(3):2899-908. Epub 2015 Mar 1 PMID: 26045798Free PMC Article

Diagnosis

Basal cell adenoma and pleomorphic adenoma of the parotid gland: a single center experience.
Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution.
Rito M, Esteves S, Fonseca I
Head Neck Pathol 2022 Dec;16(4):1157-1166. Epub 2022 Aug 10 doi: 10.1007/s12105-022-01484-z. PMID: 35947346Free PMC Article
Basal Cell Adenoma and Basal Cell Adenocarcinoma.
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
Basal Cell Adenoma of the Parotid Gland.
Amalanathan S , Kumar CS , Sinhasan SP
Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436. PMID: 34165108
Basaloid/blue salivary gland tumors.
Seethala RR
Mod Pathol 2017 Jan;30(s1):S84-S95. doi: 10.1038/modpathol.2016.190. PMID: 28060371

Therapy

Resection of benign tumours of the submandibular gland with harmonic scalpel-assisted minimally extracapsular dissection.
Hu Y, Zheng C, Cao R, Hong W, Zhang Z
J Int Med Res 2020 Jan;48(1):300060519892783. doi: 10.1177/0300060519892783. PMID: 31971033Free PMC Article
Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor.
Lee JY, Kim HJ, Kim YK, Cha J, Kim ST
Diagn Interv Radiol 2019 Jul;25(4):285-290. doi: 10.5152/dir.2019.18337. PMID: 31120425Free PMC Article
Basal cell adenoma in the parapharyngeal space resected via trans-oral approach aided by endoscopy: Case series and a review of the literature.
Wu TT, Bao YY, Zhou SH, Wang QY, Shen LF
Medicine (Baltimore) 2018 Aug;97(34):e11837. doi: 10.1097/MD.0000000000011837. PMID: 30142775Free PMC Article
Dynamic multislice computed tomography findings for parotid gland tumors.
Yerli H, Aydin E, Coskun M, Geyik E, Ozluoglu LN, Haberal N, Kaskati T
J Comput Assist Tomogr 2007 Mar-Apr;31(2):309-16. doi: 10.1097/01.rct.0000236418.82395.b3. PMID: 17414771
Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging.
Lee DK, Chung KW, Baek CH, Jeong HS, Ko YH, Son YI
J Comput Assist Tomogr 2005 Nov-Dec;29(6):884-8. doi: 10.1097/01.rct.0000183273.70422.c4. PMID: 16272868

Prognosis

Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution.
Rito M, Esteves S, Fonseca I
Head Neck Pathol 2022 Dec;16(4):1157-1166. Epub 2022 Aug 10 doi: 10.1007/s12105-022-01484-z. PMID: 35947346Free PMC Article
Basal Cell Adenoma and Basal Cell Adenocarcinoma.
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
Basal cell adenocarcinoma of the parotid gland: Comparison with basal cell adenoma for preoperative diagnosis.
Terada T, Kawata R, Higashino M, Kurisu Y, Kuwabara H, Hirose Y
Auris Nasus Larynx 2021 Apr;48(2):310-316. Epub 2020 Sep 17 doi: 10.1016/j.anl.2020.08.024. PMID: 32950324
Basal Cell Adenoma of the Parotid Gland.
Amalanathan S , Kumar CS , Sinhasan SP
Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436. PMID: 34165108
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Clinical prediction guides

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Basal cell adenoma and pleomorphic adenoma of the parotid gland: a single center experience.
Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Basal cell adenocarcinoma of the parotid gland: Comparison with basal cell adenoma for preoperative diagnosis.
Terada T, Kawata R, Higashino M, Kurisu Y, Kuwabara H, Hirose Y
Auris Nasus Larynx 2021 Apr;48(2):310-316. Epub 2020 Sep 17 doi: 10.1016/j.anl.2020.08.024. PMID: 32950324
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Basal cell adenoma of the parotid gland: clinical and pathological findings in 29 cases.
Lu J, Zhang W, Wang Z, Jia H, Ma Y, Wu H, Xiang M
Int J Clin Exp Pathol 2015;8(3):2899-908. Epub 2015 Mar 1 PMID: 26045798Free PMC Article

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