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Ossifying fibroma

MedGen UID:
104906
•Concept ID:
C0206640
•
Neoplastic Process
Synonyms: Fibroma, Ossifying; Fibromas, Ossifying; Ossifying Fibroma; Ossifying Fibromas
SNOMED CT: Cementifying fibroma (80699009); Cementifying fibroma, calcified structure (80699009); Ossifying fibroma, calcified structure (25603007); Ossifying fibroma (302862001); Ossifying fibroma (25603007); Fibro-osteoma (25603007); Fibro-osteoma (302862001); Cemento-ossifying fibroma (302863006)
 
HPO: HP:0030426
Monarch Initiative: MONDO:0002119

Definition

A benign central bone tumor composed of fibrous connective tissue within which bone is formed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOssifying fibroma

Professional guidelines

PubMed

Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management.
Koraitim M, Medra AM, Salloum AM, Shehata EA
J Craniofac Surg 2022 May 1;33(3):e265-e267. Epub 2021 Aug 13 doi: 10.1097/SCS.0000000000008085. PMID: 34387270
Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws.
Ma M, Liu L, Shi R, Zhang J, Li X, Li X, Bai J, Wang J, Huang Y, Li T
Int J Oral Sci 2021 Jun 30;13(1):21. doi: 10.1038/s41368-021-00127-3. PMID: 34188021Free PMC Article
Diagnosis and management of benign fibro-osseous lesions of the jaws: a current review for the dental clinician.
Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498

Recent clinical studies

Etiology

SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.
Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Maxillofacial fibro-osseous lesions.
MacDonald DS
Clin Radiol 2015 Jan;70(1):25-36. Epub 2014 Oct 17 doi: 10.1016/j.crad.2014.06.022. PMID: 25439185
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Diagnosis

Fibrous and Fibro-Osseous Lesions of Bone.
Chebib I, Chang CY, Lozano-Calderon S
Surg Pathol Clin 2021 Dec;14(4):707-721. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.011. PMID: 34742489
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Bone-Related Lesions of the Jaws.
Baumhoer D
Surg Pathol Clin 2017 Sep;10(3):693-704. Epub 2017 Jun 2 doi: 10.1016/j.path.2017.04.007. PMID: 28797509
Benign Fibro-Osseous Lesions of the Jaws.
Abramovitch K, Rice DD
Dent Clin North Am 2016 Jan;60(1):167-93. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.010. PMID: 26614954
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Therapy

Delayed Infection of Porous Polyethylene Implants After Oncologic Maxillectomy and Reconstruction: 2 Case Reports and Review of Literature.
Landry M, Hankins M, Berkovic J, Nathan CA
Ear Nose Throat J 2021 Dec;100(10_suppl):1023S-1026S. Epub 2020 Jun 15 doi: 10.1177/0145561320927525. PMID: 32538671
Oral and Extraoral Intermediate Tumors: Are MMP-9 and Ki-67 Biomarkers Correlated to Their High Recurrence Rates?
Afifi MM, Elnouaem MI, Omar EM, El-Komary I
Appl Immunohistochem Mol Morphol 2020 Mar;28(3):229-236. doi: 10.1097/PAI.0000000000000703. PMID: 30358613
Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.
Andreacchio A, Alberghina F, Testa G, Canavese F
Eur J Orthop Surg Traumatol 2018 Feb;28(2):291-297. Epub 2017 Aug 17 doi: 10.1007/s00590-017-2028-3. PMID: 28819829
Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report.
González-Serrano J, López-Pintor RM, Sanz-Sánchez I, Paredes VM, Casañas E, de Arriba L, Vallejo GH
Int J Periodontics Restorative Dent 2017 May/Jun;37(3):443-449. doi: 10.11607/prd.2697. PMID: 28402358
Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls.
Roitman PD, Jauk F, Farfalli GL, Albergo JI, Aponte-Tinao LA
Hum Pathol 2017 May;63:89-97. Epub 2017 Feb 22 doi: 10.1016/j.humpath.2017.02.008. PMID: 28235628

Prognosis

Skull Base Juvenile Psammomatoid Ossifying Fibroma: Clinical Characteristics, Treatment, and Prognosis.
Wang K, Ma XJ, Hao SY, Du J, Zhang LW, Zhang JT, Wu Z
World Neurosurg 2019 May;125:e843-e848. Epub 2019 Feb 8 doi: 10.1016/j.wneu.2019.01.197. PMID: 30743026
Diagnostically Challenging Epithelioid Soft Tissue Tumors.
James AW, Dry SM
Surg Pathol Clin 2015 Sep;8(3):309-29. doi: 10.1016/j.path.2015.05.002. PMID: 26297059
Psammomatoid juvenile ossifying fibroma: case study and a review.
Figueiredo LM, de Oliveira TF, Paraguassú GM, de Hollanda Valente RO, da Costa WR, Sarmento VA
Oral Maxillofac Surg 2014 Mar;18(1):87-93. Epub 2013 Feb 24 doi: 10.1007/s10006-013-0400-y. PMID: 23435579
Ossifying fibroma of the jaws: a clinical study of 14 cases and review of the literature.
Triantafillidou K, Venetis G, Karakinaris G, Iordanidis F
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Aug;114(2):193-9. Epub 2012 Feb 25 doi: 10.1016/j.tripleo.2011.07.033. PMID: 22776732
Cemento-ossifying fibroma.
More C, Thakkar K, Asrani M
Indian J Dent Res 2011 Mar-Apr;22(2):352-5. doi: 10.4103/0970-9290.84296. PMID: 21891913

Clinical prediction guides

Immunohistochemical Characterization of Gingival Fibromas.
Darling M, Li K, Burnside K, Smith N, Jackson-Boeters L, Hamilton D
Head Neck Pathol 2023 Jun;17(2):355-363. Epub 2022 Dec 6 doi: 10.1007/s12105-022-01493-y. PMID: 36472794Free PMC Article
Peripheral ossifying fibroma: A 20-year retrospective study with focus on clinical and morphological features.
Cavalcante IL, Barros CC, Cruz VM, Cunha JL, Leão LC, Ribeiro RR, Turatti E, Andrade BA, Cavalcante RB
Med Oral Patol Oral Cir Bucal 2022 Sep 1;27(5):e460-e467. doi: 10.4317/medoral.25454. PMID: 35717619Free PMC Article
SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.
Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
Benign Tumors of the Anterior Cranial Base.
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
Peripheral Cemento-Ossifying Fibroma.
Humagain M , Dawadi A , Srii R , Poudel P
Kathmandu Univ Med J (KUMJ) 2017 Jul-Sept.;15(59):261-264. PMID: 30353905

Recent systematic reviews

Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports.
R C, R S, Mohideen K, Balasubramaniam M, Ghosh S, Dhungel S
Clin Exp Dent Res 2023 Feb;9(1):186-197. Epub 2022 Nov 3 doi: 10.1002/cre2.687. PMID: 36325758Free PMC Article
Juvenile ossifying fibroma of the jaws and paranasal sinuses: a systematic review of the cases reported in the literature.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2020 Jan;49(1):28-37. Epub 2019 Jul 6 doi: 10.1016/j.ijom.2019.06.029. PMID: 31285096
Ossifying Fibromyxoid Tumor of the Retromolar Trigone: A Case Report and Systematic Review of the Literature.
Titsinides S, Nikitakis NG, Tasoulas J, Daskalopoulos A, Goutzanis L, Sklavounou A
Int J Surg Pathol 2017 Sep;25(6):526-532. Epub 2017 Apr 24 doi: 10.1177/1066896917705197. PMID: 28436288
Ossifying fibroma of the nose and paranasal sinuses.
Manes RP, Ryan MW, Batra PS, Mendelsohn D, Fang YV, Marple BF
Int Forum Allergy Rhinol 2013 Feb;3(2):161-8. Epub 2012 Jun 26 doi: 10.1002/alr.21067. PMID: 22736440
Ossifying fibroma: a systematic review.
MacDonald-Jankowski DS
Dentomaxillofac Radiol 2009 Dec;38(8):495-513. doi: 10.1259/dmfr/70933621. PMID: 20026707

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