U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced leukocyte cathepsin D activity

MedGen UID:
1050202
•Concept ID:
CN375663
•
Finding
HPO: HP:4000192

Definition

Concentration or activity of cathepsin D as measured in leukocytes is below the limits of normal. The reduction in cathepsin D activity can also be measured in fibroblasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced leukocyte cathepsin D activity

Professional guidelines

PubMed

Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1.
Zhao D, Amria S, Hossain A, Sundaram K, Komlosi P, Nagarkatti M, Haque A
Cell Immunol 2011;271(2):392-400. Epub 2011 Aug 18 doi: 10.1016/j.cellimm.2011.08.007. PMID: 21903207Free PMC Article

Recent clinical studies

Etiology

Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells.
Nakken B, Varga T, Szatmari I, Szeles L, Gyongyosi A, Illarionov PA, Dezso B, Gogolak P, Rajnavolgyi E, Nagy L
J Immunol 2011 Jul 1;187(1):240-7. Epub 2011 Jun 1 doi: 10.4049/jimmunol.1002421. PMID: 21632707
Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein S, Müller V, Köhler N, Wikman H, Krenkel S, Streichert T, Schweizer M, Riethdorf S, Assmann V, Ihnen M, Beck K, Issa R, Jänicke F, Pantel K, Milde-Langosch K
Breast Cancer Res Treat 2011 Sep;129(2):347-60. Epub 2010 Oct 23 doi: 10.1007/s10549-010-1219-y. PMID: 20972617
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux.
Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R, Marcel YL
J Biol Chem 2006 Dec 29;281(52):39971-81. Epub 2006 Oct 10 doi: 10.1074/jbc.M605095200. PMID: 17032648
Impaired function of neutrophils in uraemic patients.
Sharma A, Tripathi AK, Kalra OP, Chakrabarty AK
Natl Med J India 2000 May-Jun;13(3):121-4. PMID: 11558109

Diagnosis

Circulating microparticles as indicators of peripartum cardiomyopathy.
Walenta K, Schwarz V, Schirmer SH, Kindermann I, Friedrich EB, Solomayer EF, Sliwa K, Labidi S, Hilfiker-Kleiner D, Böhm M
Eur Heart J 2012 Jun;33(12):1469-79. Epub 2012 Feb 3 doi: 10.1093/eurheartj/ehr485. PMID: 22307461

Therapy

Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer.
Patel S, Hurez V, Nawrocki ST, Goros M, Michalek J, Sarantopoulos J, Curiel T, Mahalingam D
Oncotarget 2016 Sep 13;7(37):59087-59097. doi: 10.18632/oncotarget.10824. PMID: 27463016Free PMC Article
Circulating microparticles as indicators of peripartum cardiomyopathy.
Walenta K, Schwarz V, Schirmer SH, Kindermann I, Friedrich EB, Solomayer EF, Sliwa K, Labidi S, Hilfiker-Kleiner D, Böhm M
Eur Heart J 2012 Jun;33(12):1469-79. Epub 2012 Feb 3 doi: 10.1093/eurheartj/ehr485. PMID: 22307461

Prognosis

Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein S, Müller V, Köhler N, Wikman H, Krenkel S, Streichert T, Schweizer M, Riethdorf S, Assmann V, Ihnen M, Beck K, Issa R, Jänicke F, Pantel K, Milde-Langosch K
Breast Cancer Res Treat 2011 Sep;129(2):347-60. Epub 2010 Oct 23 doi: 10.1007/s10549-010-1219-y. PMID: 20972617

Clinical prediction guides

Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein S, Müller V, Köhler N, Wikman H, Krenkel S, Streichert T, Schweizer M, Riethdorf S, Assmann V, Ihnen M, Beck K, Issa R, Jänicke F, Pantel K, Milde-Langosch K
Breast Cancer Res Treat 2011 Sep;129(2):347-60. Epub 2010 Oct 23 doi: 10.1007/s10549-010-1219-y. PMID: 20972617
Fibrillogenic C-terminal fragment of alpha-1-antitrypsin activates human monocytes via oxidative mechanisms.
Bironaite D, Lindgren S, Janciauskiene S
Cell Tissue Res 2001 Jul;305(1):87-98. doi: 10.1007/s004410000212. PMID: 11512675
Impaired function of neutrophils in uraemic patients.
Sharma A, Tripathi AK, Kalra OP, Chakrabarty AK
Natl Med J India 2000 May-Jun;13(3):121-4. PMID: 11558109
Impaired class II expression and antigen uptake in monocytic cells after HIV-1 infection.
Polyak S, Chen H, Hirsch D, George I, Hershberg R, Sperber K
J Immunol 1997 Sep 1;159(5):2177-88. PMID: 9278305
CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity.
Alteri E, Bold G, Cozens R, Faessler A, Klimkait T, Lang M, Lazdins J, Poncioni B, Roesel JL, Schneider P
Antimicrob Agents Chemother 1993 Oct;37(10):2087-92. doi: 10.1128/AAC.37.10.2087. PMID: 8257128Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...