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Laeden paralysis

MedGen UID:
1051836
•Concept ID:
CN375721
•
Finding
HPO: HP:5200267

Definition

The sensation of having heavy arms and legs, or feeling a heaviness in the limbs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaeden paralysis

Professional guidelines

PubMed

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility.
Smith HAB, Besunder JB, Betters KA, Johnson PN, Srinivasan V, Stormorken A, Farrington E, Golianu B, Godshall AJ, Acinelli L, Almgren C, Bailey CH, Boyd JM, Cisco MJ, Damian M, deAlmeida ML, Fehr J, Fenton KE, Gilliland F, Grant MJC, Howell J, Ruggles CA, Simone S, Su F, Sullivan JE, Tegtmeyer K, Traube C, Williams S, Berkenbosch JW
Pediatr Crit Care Med 2022 Feb 1;23(2):e74-e110. doi: 10.1097/PCC.0000000000002873. PMID: 35119438
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y
Nat Rev Neurol 2019 Sep;15(9):519-539. Epub 2019 Jul 19 doi: 10.1038/s41582-019-0226-9. PMID: 31324898
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I; Movement Disorder Society-endorsed PSP Study Group
Mov Disord 2017 Jun;32(6):853-864. Epub 2017 May 3 doi: 10.1002/mds.26987. PMID: 28467028Free PMC Article

Recent clinical studies

Etiology

Diagnostics in skeletal muscle channelopathies.
Vicino A, Brugnoni R, Maggi L
Expert Rev Mol Diagn 2023 Jul-Dec;23(12):1175-1193. Epub 2023 Dec 15 doi: 10.1080/14737159.2023.2288258. PMID: 38009256
Thyrotoxic myopathy: research status, diagnosis, and treatment.
Cui H, Zhang X
Endokrynol Pol 2022;73(1):157-162. Epub 2022 Feb 4 doi: 10.5603/EP.a2022.0004. PMID: 35119093
Bilateral facial palsy.
Jung J, Park DC, Jung SY, Park MJ, Kim SH, Yeo SG
Acta Otolaryngol 2019 Oct;139(10):934-938. Epub 2019 Aug 20 doi: 10.1080/00016489.2019.1651134. PMID: 31430217
Single-paradigm and hybrid brain computing interfaces and their use by disabled patients.
de Neeling M, Van Hulle MM
J Neural Eng 2019 Oct 23;16(6):061001. doi: 10.1088/1741-2552/ab2706. PMID: 31163412
Acquired paralysis of the diaphragm.
Ko MA, Darling GE
Thorac Surg Clin 2009 Nov;19(4):501-10. doi: 10.1016/j.thorsurg.2009.08.011. PMID: 20112633

Diagnosis

Neonatal brachial plexus palsy - early diagnosis and treatment.
Berényi M, Szeredai M, Cseh Á
Ideggyogy Sz 2022 Jul 30;75(7-08):247-252. doi: 10.18071/isz.75.0247. PMID: 35916611
Frequency and Pathophysiology of Post-Seizure Todd's Paralysis.
Xu SY, Li ZX, Wu XW, Li L, Li CX
Med Sci Monit 2020 Mar 5;26:e920751. doi: 10.12659/MSM.920751. PMID: 32134903Free PMC Article
Entrapment Neuropathies of the Upper Extremity.
Doughty CT, Bowley MP
Med Clin North Am 2019 Mar;103(2):357-370. doi: 10.1016/j.mcna.2018.10.012. PMID: 30704687
Isolated Ocular Motor Nerve Palsies.
Kung NH, Van Stavern GP
Semin Neurol 2015 Oct;35(5):539-48. Epub 2015 Oct 6 doi: 10.1055/s-0035-1563568. PMID: 26444399
Locked-in syndrome.
Cardwell MS
Tex Med 2013 Feb 1;109(2):e1. PMID: 23378122

Therapy

A high-performance neuroprosthesis for speech decoding and avatar control.
Metzger SL, Littlejohn KT, Silva AB, Moses DA, Seaton MP, Wang R, Dougherty ME, Liu JR, Wu P, Berger MA, Zhuravleva I, Tu-Chan A, Ganguly K, Anumanchipalli GK, Chang EF
Nature 2023 Aug;620(7976):1037-1046. Epub 2023 Aug 23 doi: 10.1038/s41586-023-06443-4. PMID: 37612505Free PMC Article
Give me a kiss! An integrative rehabilitative training program with motor imagery and mirror therapy for recovery of facial palsy.
Paolucci T, Cardarola A, Colonnelli P, Ferracuti G, Gonnella R, Murgia M, Santilli V, Paoloni M, Bernetti A, Agostini F, Mangone M
Eur J Phys Rehabil Med 2020 Feb;56(1):58-67. Epub 2019 Mar 27 doi: 10.23736/S1973-9087.19.05757-5. PMID: 30916916
Perseverance is required!
Curt A
Spinal Cord 2019 May;57(5):347. Epub 2019 Apr 8 doi: 10.1038/s41393-019-0277-1. PMID: 30962517
Efficacy of Short-Term Robot-Assisted Rehabilitation in Patients With Hand Paralysis After Stroke: A Randomized Clinical Trial.
Villafañe JH, Taveggia G, Galeri S, Bissolotti L, Mullè C, Imperio G, Valdes K, Borboni A, Negrini S
Hand (N Y) 2018 Jan;13(1):95-102. Epub 2017 Feb 16 doi: 10.1177/1558944717692096. PMID: 28719996Free PMC Article
Facial exercise therapy for facial palsy: systematic review and meta-analysis.
Pereira LM, Obara K, Dias JM, Menacho MO, Lavado EL, Cardoso JR
Clin Rehabil 2011 Jul;25(7):649-58. Epub 2011 Mar 7 doi: 10.1177/0269215510395634. PMID: 21382865

Prognosis

A framework for the evaluation of patients with congenital facial weakness.
Webb BD, Manoli I, Engle EC, Jabs EW
Orphanet J Rare Dis 2021 Apr 7;16(1):158. doi: 10.1186/s13023-021-01736-1. PMID: 33827624Free PMC Article
Bell's Palsy-Retroauricular Pain Threshold.
Kopitović A, Katanić F, Kalember S, Simić S, Vico N, Sekulić S
Medicina (Kaunas) 2021 Mar 13;57(3) doi: 10.3390/medicina57030263. PMID: 33805591Free PMC Article
Cracking the neural code, treating paralysis and the future of bioelectronic medicine.
Bouton C
J Intern Med 2017 Jul;282(1):37-45. Epub 2017 Apr 16 doi: 10.1111/joim.12610. PMID: 28419590
Facial reanimations: part I--recent paralyses.
Biglioli F
Br J Oral Maxillofac Surg 2015 Dec;53(10):901-6. Epub 2015 Jul 15 doi: 10.1016/j.bjoms.2015.06.023. PMID: 26188934
Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center.
Hohman MH, Hadlock TA
Laryngoscope 2014 Jul;124(7):E283-93. Epub 2014 Jan 15 doi: 10.1002/lary.24542. PMID: 24431233

Clinical prediction guides

Gastroparesis.
Camilleri M, Sanders KM
Gastroenterology 2022 Jan;162(1):68-87.e1. Epub 2021 Oct 27 doi: 10.1053/j.gastro.2021.10.028. PMID: 34717924Free PMC Article
Frequency and Pathophysiology of Post-Seizure Todd's Paralysis.
Xu SY, Li ZX, Wu XW, Li L, Li CX
Med Sci Monit 2020 Mar 5;26:e920751. doi: 10.12659/MSM.920751. PMID: 32134903Free PMC Article
The Modified Tardieu Scale for the measurement of elbow flexor spasticity in adult patients with hemiplegia.
Ansari NN, Naghdi S, Hasson S, Azarsa MH, Azarnia S
Brain Inj 2008 Dec;22(13-14):1007-12. doi: 10.1080/02699050802530557. PMID: 19117179
The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability.
Eliasson AC, Krumlinde-Sundholm L, Rösblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P
Dev Med Child Neurol 2006 Jul;48(7):549-54. doi: 10.1017/S0012162206001162. PMID: 16780622
Prechtl's assessment of general movements: a diagnostic tool for the functional assessment of the young nervous system.
Einspieler C, Prechtl HF
Ment Retard Dev Disabil Res Rev 2005;11(1):61-7. doi: 10.1002/mrdd.20051. PMID: 15856440

Recent systematic reviews

Physical therapy for facial nerve paralysis (Bell's palsy): An updated and extended systematic review of the evidence for facial exercise therapy.
Khan AJ, Szczepura A, Palmer S, Bark C, Neville C, Thomson D, Martin H, Nduka C
Clin Rehabil 2022 Nov;36(11):1424-1449. Epub 2022 Jul 5 doi: 10.1177/02692155221110727. PMID: 35787015Free PMC Article
Effectiveness of kinesiology taping on the functions of upper limbs in patients with stroke: a meta-analysis of randomized trial.
Wang Y, Li X, Sun C, Xu R
Neurol Sci 2022 Jul;43(7):4145-4156. Epub 2022 Mar 26 doi: 10.1007/s10072-022-06010-1. PMID: 35347525Free PMC Article
Efficacy of rehabilitative techniques in reducing hemiplegic shoulder pain in stroke: Systematic review and meta-analysis.
de Sire A, Moggio L, Demeco A, Fortunato F, Spanò R, Aiello V, Marotta N, Ammendolia A
Ann Phys Rehabil Med 2022 Sep;65(5):101602. Epub 2021 Nov 19 doi: 10.1016/j.rehab.2021.101602. PMID: 34757009
Acute Peripheral Facial Palsy: Recent Guidelines and a Systematic Review of the Literature.
Kim SJ, Lee HY
J Korean Med Sci 2020 Aug 3;35(30):e245. doi: 10.3346/jkms.2020.35.e245. PMID: 32743989Free PMC Article
A systematic review of variables associated with sleep paralysis.
Denis D, French CC, Gregory AM
Sleep Med Rev 2018 Apr;38:141-157. Epub 2017 Jun 8 doi: 10.1016/j.smrv.2017.05.005. PMID: 28735779

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